Crystal engineering of MOF@COF core-shell composites for ultra-sensitively electrochemical detection

Exploration and construction of novel porous core-shell composites is of crucial significance due to their prospectively enhanced performances and far-ranging applications. Herein, microporous UiO-66-NH2 as a MOF core is coated by a mesoporous TAPB-DMTP-COF shell to construct the UiO-66-NH2@COF composite via a covalent linking approach. Importantly, the composite with retentive crystallinity and hierarchical porosity significantly improves the electrochemical detection performance, for instance ATP and antibiotic, because this composite has the high affinity between the phosphate groups of aptamers and dense Zr(IV) sites, and strong pi-pi stacking interaction between aptamers and this MOF@COF. The synthetic strategy in this systematic research expands a rational design for other MOF@COF core-shell hybrid materials to expand their promising applications.