A new synthesis of 3-alkyl-1-isoindolinones

被引：46

作者：

Wang, EC ^{[1
]}

Chen, HF ^{[1
]}

Feng, PK ^{[1
]}

Lin, YL ^{[1
]}

Hsu, MK ^{[1
]}

机构：

[1] Kaohsiung Med Univ, Sch Chem, Kaohsiung 807, Taiwan

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 50期

关键词：

D O I：

10.1016/S0040-4039(02)02273-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new, concise, and efficient method for the synthesis of 3-alkyl-1-isoindolinones was described. 3-Alkyl-3-hydroxy-2,3-dihydro-1-isoindolinones, prepared from the reaction of phthalimide and alkyl lithium, were treated with sodium cyanoborohydride in acidic medium to concomitantly undergo dehydration and reduction leading to various 3-alkyl-1-isoindolinones in good yields. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：9163 / 9165

页数：3

共 17 条

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