Potencies of phosphine peptide inhibitors of mammalian thimet oligopeptidase and neurolysin on two bacterial Pz peptidases

被引：6

作者：

Sugihara, Yusuke ^{[1
]}

Kawasaki, Akio ^{[1
]}

Tsujimoto, Yoshiyuki ^{[1
]}

Matsui, Hiroshi ^{[1
]}

Watanage, Kunihiko ^{[1
]}

机构：

[1] Kyoto Prefectural Univ, Dept Appl Biochem, Kyoto 6068522, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2007年 / 71卷 / 02期

关键词：

Pz-peptidase; thimet oligopeptidase; neurolysin; phosphine peptide; oligopeptidase;

D O I：

10.1271/bbb.60534

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pz peptidases A and bacillus collagenovorans B, from a thermophile Geo-bacillus recognize collagen-specific tripeptide units (Gly-Pro-Xaa). They share similarities in function but extremely low identities in primary sequence with mammalian thimet oligopeptidase (TOP) and neurolysin. Three phosphine peptide inhibitors that selectively inhibit TOP and neurolysin on two bacterial Pz peptidases were investigated. They showed potent inhibition of both Pz peptidases in a range from 10 to 100 nm.

引用

页码：594 / 597

页数：4

共 3 条

[1] Substrate specificity characterization of recombinant metallo oligo-peptidases thimet oligopeptidase and neurolysin
Oliveira, V
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Melo, RL
Ferro, ES
Camargo, ACM
Juliano, MA
Juliano, L
BIOCHEMISTRY, 2001, 40 (14) : 4417 - 4425
[2] Two thimet oligopeptidase-like Pz peptidases produced by a collagen-degrading thermophile, Geobacillus collagenovorans MO-1
Miyake, R
Shigeri, Y
Tatsu, Y
Yumoto, N
Umekawa, M
Tsujimoto, Y
Matsui, H
Watanabe, K
JOURNAL OF BACTERIOLOGY, 2005, 187 (12) : 4140 - 4148
[3] The Exquisite Structure and Reaction Mechanism of Bacterial Pz-peptidase A toward Collagenous Peptides X-RAY CRYSTALLOGRAPHIC STRUCTURE ANALYSIS OF PZ-PEPTIDASE A REVEALS DIFFERENCES FROM MAMMALIAN THIMET OLIGOPEPTIDASE
Kawasaki, Akio
Nakano, Hiroaki
Hosokawa, Allin
Nakatsu, Toru
Kato, Hiroaki
Watanabe, Kunihiko
JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (45) : 34972 - 34980

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