Depth-Resolved Optical Monitoring of Neural Activity in Freely Moving Animals

被引：1

作者：

Pisano, Filippo ^{[1
]}

Pisanello, Marco ^{[1
]}

Lee, Suk Joon ^{[2
]}

Lee, Jaeeon ^{[2
]}

Maglie, Emanuela ^{[1
,3
]}

Balena, Antonio ^{[1
,3
]}

Sileo, Leonardo ^{[1
]}

Spagnolo, Barbara ^{[1
]}

Bianco, Marco ^{[1
,3
]}

Hyun, Minsuk ^{[2
]}

Sabatini, Bernardo L. ^{[2
]}

de Vittorio, Massimo ^{[1
,3
]}

Pisanello, Ferruccio ^{[1
]}

机构：

[1] Ist Italiano Tecnol, Ctr Biomol Nanotechnol, Arnesano, Italy

[2] Harvard Med Sch, Howard Hughes Med Inst, Dept Neurobiol, Boston, MA 02115 USA

[3] Univ Salento, Dip Ingn Innovaz, Lecce, Italy

来源：

2020 22ND INTERNATIONAL CONFERENCE ON TRANSPARENT OPTICAL NETWORKS (ICTON 2020) | 2020年

基金：

美国国家卫生研究院; 欧洲研究理事会;

关键词：

neuro-photonics; fiber photometry; tapered optical fibers; FIBERS;

D O I：

10.1109/icton51198.2020.9203401

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

Fiber photometry techniques are widely used to monitor neural activity of genetically-targeted neural populations in behaving animals However, most implementations rely on flat-cleaved optical fibers that can only interface with shallow tissue volumes adjacent to the fiber tip due to the high scattering of brain tissue. Here we review our work on circumventing this important limitation by exploiting mode division demultiplexing using tapered optical fibers to collect photons at multiple depths simultaneously.

引用

页数：4