Stimulation of the Immune System by Therapeutic Antisense Oligodeoxynucleotides and Small Interfering RNAs via Nucleic Acid Receptors How to Avoid Immune Activation

被引：10

作者：

Richardt-Pargmann, Denise ^{[1
]}

Vollmer, Joerg ^{[1
]}

机构：

[1] Pfizer Co, Coley Pharmaceut GmbH, D-40225 Dusseldorf, Germany

来源：

OLIGONUCLEOTIDE THERAPEUTICS | 2009年 / 1175卷

关键词：

siRNA; antisense; immune stimulation; in vivo delivery; TLR; ENDOTHELIAL GROWTH-FACTOR; TOLL-LIKE RECEPTORS; PLASMACYTOID DENDRITIC CELLS; POLYELECTROLYTE COMPLEX MICELLES; INHIBITS TUMOR-GROWTH; SINGLE-STRANDED RNA; IN-VIVO; BACTERIAL-DNA; CPG MOTIFS; RIG-I;

D O I：

10.1111/j.1749-6632.2009.04971.x

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Most of the therapeutic applications for synthetic oligodeoxynucleotides (ODN) and oligoribonucleotides (ORN) relate to mechanisms of manipulating gene expression based on Watson-Crick base pairing to endogenous nucleic acids. However, in recent years it has become apparent that the immune system has evolved defense mechanisms against infections that are based on the detection of infecting viral and bacterial nucleic acids. In some cases, synthetic ODN and ORN can trigger these defenses and, therefore, can interfere with or distort the mechanism of action of antisense ODN or small interfering RNAs.

引用

页码：40 / 54

页数：15

共 123 条

[1] RNAi therapeutics: Principles, prospects and challenges [J].

Aagaard, Lars ;

Rossi, John J. .

ADVANCED DRUG DELIVERY REVIEWS, 2007, 59 (2-3) :75-86

[2]

Abraham D, 2008, FRONT BIOSCI, V13, P5571

[3] Antisense and siRNA as agonists of Toll-like receptors [J].

Agrawal, S ;

Kandimalla, ER .

NATURE BIOTECHNOLOGY, 2004, 22 (12) :1533-1537

[4] Delivery systems for the direct application of siRNAs to induce RNA interference (RNAi) in vivo [J].

Aigner, Achim .

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2006,

[5] Nonviral delivery of synthetic siRNAs in vivo [J].

Akhtar, Saghir ;

Benter, Ibrahim F. .

JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (12) :3623-3632

[6] Ex vivo and in vivo delivery of anti-tissue factor short interfering RNA inhibits mouse pulmonary metastasis of B16 melanoma cells [J].

Amarzguioui, Mohammed ;

Peng, Qian ;

Wiiger, Merete T. ;

Vasovic, Vlada ;

Babaie, Eshrat ;

Holen, Torgeir ;

Nesland, Jahn M. ;

Prydz, Hans .

CLINICAL CANCER RESEARCH, 2006, 12 (13) :4055-4061

[7]

Ballas ZK, 1996, J IMMUNOL, V157, P1840

[8] Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging [J].

Bartlett, Derek W. ;

Su, Helen ;

Hildebrandt, Isabel J. ;

Weber, Wolfgang A. ;

Davis, Mark E. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (39) :15549-15554

[9] Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA [J].

Barton, GM ;

Kagan, JC ;

Medzhitov, R .

NATURE IMMUNOLOGY, 2006, 7 (01) :49-56

[10] Recognition of nucleic acid and nucleic acid analogs by Toll-like receptors 7, 8 and 9 [J].

Bauer, Stefan ;

Pigisch, Stephanie ;

Hangel, Doris ;

Kaufmann, Andreas ;

Hamm, Svetlana .

IMMUNOBIOLOGY, 2008, 213 (3-4) :315-328

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