Reactive oxygen species-responsive drug delivery systems for the treatment of neurodegenerative diseases

被引：98
作者：
Ballance, William C. [1 ]
Qin, Ellen C. [2 ]
Chung, Hee Jung [3 ,4 ,5 ]
Gillette, Martha U. [3 ,4 ,5 ,6 ]
Kong, Hyunjoon [1 ,4 ]
机构：
[1] Univ Illinois, Dept Chem & Biomol Engn, Urbana, IL USA
[2] Univ Illinois, Dept Mat Sci & Engn, Urbana, IL USA
[3] Univ Illinois, Dept Mol & Integrat Physiol, Urbana, IL USA
[4] Univ Illinois, Beckman Inst Adv Sci & Technol, Urbana, IL USA
[5] Univ Illinois, Neurosci Program, Urbana, IL USA
[6] Univ Illinois, Dept Cell & Dev Biol, Urbana, IL USA
来源：
BIOMATERIALS | 2019年 / 217卷
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
Reactive oxygen species; Neuroinflammation; Neurological disorders; Drug delivery; BLOOD-BRAIN-BARRIER; CERIUM OXIDE NANOPARTICLES; COMPLEX I DEFICIENCY; OXIDATIVE STRESS; HYDROGEN-PEROXIDE; ALZHEIMERS-DISEASE; AMYLOID-BETA; HUNTINGTONS-DISEASE; LIPID-PEROXIDATION; NADPH OXIDASE;
D O I：
10.1016/j.biomaterials.2019.119292
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Neurodegenerative diseases and disorders seriously impact memory and cognition and can become life-threatening. Current medical techniques attempt to combat these detrimental effects mainly through the administration of neuromedicine. However, drug efficacy is limited by rapid dispersal of the drugs to off-target sites while the site of administration is prone to overdose. Many neuropathological conditions are accompanied by excessive reactive oxygen species (ROS) due to the inflammatory response. Accordingly, ROS-responsive drug delivery systems have emerged as a promising solution. To guide intelligent and comprehensive design of ROS-responsive drug delivery systems, this review article discusses the two following topics: (1) the biology of ROS in both healthy and diseased nervous systems and (2) recent developments in ROS-responsive, drug delivery system design. Overall, this review article would assist efforts to make better decisions about designing ROS-responsive, neural drug delivery systems, including the selection of ROS-responsive functional groups.
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页数：19
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