Ubiquitin system: JAMMing in the name of the lid

被引：13

作者：

Berndt, C

Bech-Otschir, D

Dubiel, W

Seeger, M

机构：

[1] Humboldt Univ, Dept Surg, Div Mol Biol, D-10117 Berlin, Germany

[2] Humboldt Univ, Fac Med, Charite, Inst Biochem, D-10117 Berlin, Germany

来源：

CURRENT BIOLOGY | 2002年 / 12卷 / 23期

关键词：

D O I：

10.1016/S0960-9822(02)01317-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The isopeptide bonds formed by ubiquitin or its relatives are cleaved by hydrolases with active site cysteines. Recent studies have revealed that similar metalloprotease motifs - JAMMs - in the Rpn11 subunit of the 26S proteasome lid and in the Csn5 subunit of the COP9 signalosome are involved in deubiquitination and deneddylation, respectively.

引用

收藏

页码：R815 / R817

页数：3

相关论文

共 17 条

[1]

Bech-Otschir D, 2002, J CELL SCI, V115, P467

[2] The base of the proteasome regulatory particle exhibits chaperone-like activity [J].

Braun, BC ;

Glickman, M ;

Kraft, R ;

Dahlmann, B ;

Kloetzel, PM ;

Finley, D ;

Schmidt, M .

NATURE CELL BIOLOGY, 1999, 1 (04) :221-226

[3] Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1 [J].

Cope, GA ;

Suh, GSB ;

Aravind, L ;

Schwarz, SE ;

Zipursky, SL ;

Koonin, EV ;

Deshaies, RJ .

SCIENCE, 2002, 298 (5593) :608-611

[4]

EYTAN E, 1993, J BIOL CHEM, V268, P4668

[5] A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3 [J].

Glickman, MH ;

Rubin, DM ;

Coux, O ;

Wefes, I ;

Pfeifer, G ;

Cjeka, Z ;

Baumeister, W ;

Fried, VA ;

Finley, D .

CELL, 1998, 94 (05) :615-623

[6] Comparison of human COP9 signalosome and 26S proteasome 'lid' [J].

Henke, W ;

Ferrell, K ;

Bech-Otschir, D ;

Seeger, M ;

Schade, R ;

Jungblut, P ;

Naumann, M ;

Dubiel, W .

MOLECULAR BIOLOGY REPORTS, 1999, 26 (1-2) :29-34

[7] The ubiquitin system [J].

Hershko, A ;

Ciechanover, A .

ANNUAL REVIEW OF BIOCHEMISTRY, 1998, 67 :425-479

[8] Ubiquitin and its kin: how close are the family ties? [J].

Jentsch, S ;

Pyrowolakis, G .

TRENDS IN CELL BIOLOGY, 2000, 10 (08) :335-342

[9] NEDD8 recruits E2-ubiquitin to SCF E3 ligase [J].

Kawakami, T ;

Chiba, T ;

Suzuki, T ;

Iwai, K ;

Yamanaka, K ;

Minato, N ;

Suzuki, H ;

Shimbara, N ;

Hidaka, Y ;

Osaka, F ;

Omata, M ;

Tanaka, K .

EMBO JOURNAL, 2001, 20 (15) :4003-4012

[10] A proteasomal ATPase subunit recognizes the polyubiquitin degradation signal [J].

Lam, YA ;

Lawson, TG ;

Velayutham, M ;

Zweier, JL ;

Pickart, CM .

NATURE, 2002, 416 (6882) :763-767