Extracellular Vesicles in Cardiovascular Diseases: Alternative Biomarker Sources, Therapeutic Agents, and Drug Delivery Carriers

被引：93

作者：

Chong, Suet Yen ^{[1
,2
]}

Lee, Choon Keong ^{[3
]}

Huang, Chenyuan ^{[1
,2
]}

Ou, Yi Hsuan ^{[3
]}

Charles, Christopher J. ^{[1
,2
]}

Richards, Arthur Mark ^{[2
,4
]}

Neupane, Yub Raj ^{[3
]}

Pavon, Maria Vazquez ^{[3
]}

Zharkova, Olga ^{[1
,2
]}

Pastorin, Giorgia ^{[3
]}

Wang, Jiong-Wei ^{[1
,2
,5
]}

机构：

[1] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Surg, Singapore 119228, Singapore

[2] NUHCS, Cardiovasc Res Inst CVRI, Singapore 117599, Singapore

[3] Natl Univ Singapore, Dept Pharm, Singapore 117543, Singapore

[4] Natl Univ Singapore Hosp, Dept Med, Singapore 119228, Singapore

[5] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Physiol, Singapore 117593, Singapore

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 13期

基金：

英国医学研究理事会;

关键词：

extracellular vesicles; cardiovascular disease; biomarker; therapeutic; drug delivery; theranostics; CELL-DERIVED EXOSOMES; PLURIPOTENT STEM-CELLS; CARDIOMYOCYTE APOPTOSIS; ISCHEMIA-REPERFUSION; CARDIAC REGENERATION; INDUCE ANGIOGENESIS; ENDOTHELIAL-CELLS; TARGETED DELIVERY; ADIPOSE-TISSUE; PROTEIN-LEVELS;

D O I：

10.3390/ijms20133272

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cardiovascular diseases (CVD) represent the leading cause of morbidity and mortality globally. The emerging role of extracellular vesicles (EVs) in intercellular communication has stimulated renewed interest in exploring the potential application of EVs as tools for diagnosis, prognosis, and therapy in CVD. The ubiquitous nature of EVs in biological fluids presents a technological advantage compared to current diagnostic tools by virtue of their notable stability. EV contents, such as proteins and microRNAs, represent specific signatures of cellular activation or injury. This feature positions EVs as an alternative source of biomarkers. Furthermore, their intrinsic activity and immunomodulatory properties offer EVs unique opportunities to act as therapeutic agents per se or to serve as drug delivery carriers by acting as miniaturized vehicles incorporating bioactive molecules. In this article, we aim to review the recent advances and applications of EV-based biomarkers and therapeutics. In addition, the potential of EVs as a drug delivery and theranostic platform for CVD will also be discussed.

引用

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