Acute kidney injury in acute on chronic liver failure

被引:35
作者
Maiwall, Rakhi [1 ]
Sarin, S. K. [1 ]
Moreau, Richard [2 ,3 ,4 ,5 ]
机构
[1] Inst Liver & Biliary Sci, Dept Hepatol, D1 Vasantkunj, New Delhi 110070, India
[2] INSERM, CRI, U1149, Paris, France
[3] Univ Paris 07, UMRS1149, Paris, France
[4] Hop Beaujon, AP HP, DHU UNITY, Serv Hepatol, Clichy, France
[5] PRES Sorbonne Paris Cite, Lab Excellence Inflamex, Paris, France
关键词
ACLF; AKI; APASL; EASL-CLIF; TYPE-1; HEPATORENAL-SYNDROME; SEVERE ALCOHOLIC HEPATITIS; RENAL REPLACEMENT THERAPY; GELATINASE-ASSOCIATED LIPOCALIN; ACUTE TUBULAR-NECROSIS; DIFFERENTIAL-DIAGNOSIS; IMPROVES SURVIVAL; CYSTATIN-C; CONSENSUS RECOMMENDATIONS; TRANSPLANT RECIPIENTS;
D O I
10.1007/s12072-015-9652-y
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Acute on chronic liver failure (ACLF) is a distinct clinical entity; however, there is still debate in the way it is defined in the East as compared to the West, especially with respect to incorporation of kidney dysfunction or failure in the definition of ACLF. Kidney dysfunction is defined as serum creatinine between 1.5 and 1.9 mg/dl and kidney failure as serum creatinine of more than 2 mg/dl or requirement of renal replacement therapy according to the EASL-CLIF Consortium. Kidney dysfunction or failure is universally present in patients with ACLF according to the definition by the EASL-CLIF Consortium while on the contrary the APASL definition of ACLF does not incorporate kidney dysfunction or failure in its definition. Recently, both the diagnosis and management of renal failure in patients with cirrhosis has changed with the advent of the acute kidney injury (AKI) criteria defined as an abrupt decline in renal functions, characterized by an absolute increase in serum creatinine of 0.3 mg/dl within 48 h or an increase of more than 50 % from baseline, which is known or presumed to have occurred in the previous 7 days. Further, recent studies in patients with cirrhosis have shown the utility of biomarkers for the diagnosis of AKI. The present review covers the pathogenetic mechanisms, diagnosis, prognosis as well as management of AKI in patients with ACLF from both a Western as well as an Eastern perspective. The review identifies an unmet need to diagnose AKI and prevent this ominous complication in patients with ACLF.
引用
收藏
页码:245 / 257
页数:13
相关论文
共 97 条
[1]   Current concepts - Normotensive ischemic acute renal failure [J].
Abuelo, J. Gary .
NEW ENGLAND JOURNAL OF MEDICINE, 2007, 357 (08) :797-805
[2]   Changing Options for Prevention and Treatment of Infections in Cirrhosis [J].
Juan Acevedo ;
Verónica Prado ;
Javier Fernández .
Current Treatment Options in Gastroenterology, 2014, 12 (2) :256-267
[3]   Serum Cystatin Cas an Indicator of Renal Function and Mortality in Liver Transplant Recipients [J].
Allen, Alina M. ;
Kim, W. Ray ;
Larson, Joseph J. ;
Colby, Colin ;
Therneau, Terry M. ;
Rule, Andrew D. .
TRANSPLANTATION, 2015, 99 (07) :1431-1435
[4]   Acute Kidney Injury Is an Early Predictor of Mortality for Patients With Alcoholic Hepatitis [J].
Altamirano, Jose ;
Fagundes, Claudia ;
Dominguez, Marlene ;
Garcia, Elisabet ;
Michelena, Javier ;
Cardenas, Andres ;
Guevara, Monica ;
Pereira, Gustavo ;
Torres-Vigil, Karina ;
Arroyo, Vicente ;
Caballeria, Juan ;
Gines, Pere ;
Bataller, Ramon .
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2012, 10 (01) :65-U147
[5]   Pathogenesis and management of hepatorenal syndrome in patients with cirrhosis [J].
Angeli, Paolo ;
Merkel, Carlo .
JOURNAL OF HEPATOLOGY, 2008, 48 :S93-S103
[6]   Diagnosis and management of acute kidney injury in patients with cirrhosis: revised consensus recommendations of the International Club of Ascites [J].
Angeli, Paolo ;
Gines, Pere ;
Wong, Florence ;
Bernardi, Mauro ;
Boyer, Thomas D. ;
Gerbes, Alexander ;
Moreau, Richard ;
Jalan, Rajiv ;
Sarin, Shiv K. ;
Piano, Salvatore ;
Moore, Kevin ;
Lee, Samuel S. ;
Durand, Francois ;
Salerno, Francesco ;
Caraceni, Paolo ;
Kim, W. Ray ;
Arroyo, Vicente ;
Garcia-Tsao, Guadalupe .
GUT, 2015, 64 (04) :531-537
[7]   Pentoxifylline: A first line treatment option for severe alcoholic hepatitis and hepatorenal syndrome? [J].
Assimakopoulos, Stelios F. ;
Thomopoulos, Konstantinos C. ;
Labropoulou-Karatza, Chrisoula .
WORLD JOURNAL OF GASTROENTEROLOGY, 2009, 15 (25) :3194-3195
[8]   Urinary biochemistry and microscopy in septic acute renal failure: A systematic review [J].
Bagshaw, Sean M. ;
Langenberg, Christoph ;
Bellomo, Rinaldo .
AMERICAN JOURNAL OF KIDNEY DISEASES, 2006, 48 (05) :695-705
[9]   Survival in Infection-Related Acute-on-Chronic Liver Failure Is Defined by Extrahepatic Organ Failures [J].
Bajaj, Jasmohan S. ;
O'Leary, Jacqueline G. ;
Reddy, K. Rajender ;
Wong, Florence ;
Biggins, Scott W. ;
Patton, Heather ;
Fallon, Michael B. ;
Garcia-Tsao, Guadalupe ;
Maliakkal, Benedict ;
Malik, Raza ;
Subramanian, Ram M. ;
Thacker, Leroy R. ;
Kamath, Patrick S. .
HEPATOLOGY, 2014, 60 (01) :250-256
[10]   Second Infections Independently Increase Mortality in Hospitalized Patients With Cirrhosis: The North American Consortium for the Study of End-Stage Liver Disease (NACSELD) Experience [J].
Bajaj, Jasmohan S. ;
O'Leary, Jacqueline G. ;
Reddy, K. Rajender ;
Wong, Florence ;
Olson, Jody C. ;
Subramanian, Ram M. ;
Brown, Geri ;
Noble, Nicole A. ;
Thacker, Leroy R. ;
Kamath, Patrick S. .
HEPATOLOGY, 2012, 56 (06) :2328-2335