共 97 条
Acute kidney injury in acute on chronic liver failure
被引:35
作者:

Maiwall, Rakhi
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机构:
Inst Liver & Biliary Sci, Dept Hepatol, D1 Vasantkunj, New Delhi 110070, India Inst Liver & Biliary Sci, Dept Hepatol, D1 Vasantkunj, New Delhi 110070, India

Sarin, S. K.
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h-index: 0
机构:
Inst Liver & Biliary Sci, Dept Hepatol, D1 Vasantkunj, New Delhi 110070, India Inst Liver & Biliary Sci, Dept Hepatol, D1 Vasantkunj, New Delhi 110070, India

Moreau, Richard
论文数: 0 引用数: 0
h-index: 0
机构:
INSERM, CRI, U1149, Paris, France
Univ Paris 07, UMRS1149, Paris, France
Hop Beaujon, AP HP, DHU UNITY, Serv Hepatol, Clichy, France
PRES Sorbonne Paris Cite, Lab Excellence Inflamex, Paris, France Inst Liver & Biliary Sci, Dept Hepatol, D1 Vasantkunj, New Delhi 110070, India
机构:
[1] Inst Liver & Biliary Sci, Dept Hepatol, D1 Vasantkunj, New Delhi 110070, India
[2] INSERM, CRI, U1149, Paris, France
[3] Univ Paris 07, UMRS1149, Paris, France
[4] Hop Beaujon, AP HP, DHU UNITY, Serv Hepatol, Clichy, France
[5] PRES Sorbonne Paris Cite, Lab Excellence Inflamex, Paris, France
关键词:
ACLF;
AKI;
APASL;
EASL-CLIF;
TYPE-1;
HEPATORENAL-SYNDROME;
SEVERE ALCOHOLIC HEPATITIS;
RENAL REPLACEMENT THERAPY;
GELATINASE-ASSOCIATED LIPOCALIN;
ACUTE TUBULAR-NECROSIS;
DIFFERENTIAL-DIAGNOSIS;
IMPROVES SURVIVAL;
CYSTATIN-C;
CONSENSUS RECOMMENDATIONS;
TRANSPLANT RECIPIENTS;
D O I:
10.1007/s12072-015-9652-y
中图分类号:
R57 [消化系及腹部疾病];
学科分类号:
摘要:
Acute on chronic liver failure (ACLF) is a distinct clinical entity; however, there is still debate in the way it is defined in the East as compared to the West, especially with respect to incorporation of kidney dysfunction or failure in the definition of ACLF. Kidney dysfunction is defined as serum creatinine between 1.5 and 1.9 mg/dl and kidney failure as serum creatinine of more than 2 mg/dl or requirement of renal replacement therapy according to the EASL-CLIF Consortium. Kidney dysfunction or failure is universally present in patients with ACLF according to the definition by the EASL-CLIF Consortium while on the contrary the APASL definition of ACLF does not incorporate kidney dysfunction or failure in its definition. Recently, both the diagnosis and management of renal failure in patients with cirrhosis has changed with the advent of the acute kidney injury (AKI) criteria defined as an abrupt decline in renal functions, characterized by an absolute increase in serum creatinine of 0.3 mg/dl within 48 h or an increase of more than 50 % from baseline, which is known or presumed to have occurred in the previous 7 days. Further, recent studies in patients with cirrhosis have shown the utility of biomarkers for the diagnosis of AKI. The present review covers the pathogenetic mechanisms, diagnosis, prognosis as well as management of AKI in patients with ACLF from both a Western as well as an Eastern perspective. The review identifies an unmet need to diagnose AKI and prevent this ominous complication in patients with ACLF.
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页码:245 / 257
页数:13
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机构:
Virginia Commonwealth Univ, Div Gastroenterol Hepatol & Nutr, Richmond, VA 23249 USA
McGuire VA Med Ctr, Richmond, VA 23249 USA Virginia Commonwealth Univ, Div Gastroenterol Hepatol & Nutr, Richmond, VA 23249 USA

Thacker, Leroy R.
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机构:
McGuire VA Med Ctr, Richmond, VA 23249 USA
Virginia Commonwealth Univ, Richmond, VA USA Virginia Commonwealth Univ, Div Gastroenterol Hepatol & Nutr, Richmond, VA 23249 USA

Kamath, Patrick S.
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机构:
Mayo Clin, Sch Med, Div Gastroenterol & Hepatol, Rochester, MN USA Virginia Commonwealth Univ, Div Gastroenterol Hepatol & Nutr, Richmond, VA 23249 USA