Embracing the Enemy: Cell-to-Cell Force Transmission Enhances Cytotoxicity

被引：1
|
作者：
Roy, Nathan H. [1 ,2 ]
Burkhardt, Janis K. [1 ,2 ]
机构：
[1] Childrens Hosp Philadelphia, Res Inst, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA
[2] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA
来源：
DEVELOPMENTAL CELL | 2016年 / 36卷 / 06期
关键词：
IMMUNOLOGICAL SYNAPSE;
D O I：
10.1016/j.devcel.2016.03.007
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Cells respond to the mechanical properties of their environment, but how biomechanics contributes to intercellular signaling remains unclear. Reporting in Cell, Basu et al. (2016) showed that forces exerted by cytotoxic T lymphocytes enhance the function of the pore-forming protein perforin, thereby leading to more effective target cell killing.
引用
收藏
页码：592 / 594
页数：4
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