Efficient radiolabeling of rutin with 125I and biodistribution study of radiolabeled rutin

被引：21

作者：

Choi, Mi Hee ^{[1
]}

Rho, Jong Kook ^{[1
]}

Kang, Jung Ae ^{[1
]}

Shim, Ha Eun ^{[1
]}

Nam, You Ree ^{[1
]}

Yoon, Seonhye ^{[1
,2
]}

Kim, Hye Rim ^{[1
]}

Choi, Dae Seong ^{[1
]}

Park, Sang Hyun ^{[1
,2
]}

Jang, Beom-Su ^{[1
,2
]}

Jeon, Jongho ^{[1
,2
]}

机构：

[1] Korea Atom Energy Res Inst, Adv Radiat Technol Inst, Jeongeup 580185, South Korea

[2] Univ Sci & Technol, Dept Radiat Biotechnol & Appl Radioisotope Sci, Daejeon 305350, South Korea

来源：

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY | 2016年 / 308卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

Rutin; Radiolabeling; I-125; SPECT/CT; Biodistribution; QUERCETIN; ABSORPTION; PHARMACOKINETICS; EXTRACTION; RAT;

D O I：

10.1007/s10967-015-4415-8

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The purpose of the current research is to synthesize radiolabeled rutin for biodistribution study and SPECT/CT image of rutin. The optimized radiolabeling condition provided I-125-labeled rutin with 53.5 % of radiochemical yield. Most of orally administered I-125-labeled rutin was initially found in the stomach and small intestine and a portion of the product was then distributed in internal organs. While intravenously injected I-125-labeled rutin was accumulated in liver and then a large part of it was transferred to small intestine. The present results provided an efficient radiolabeling method of flavonoid glycoside as well as quantitative organ distribution of rutin.

引用

页码：477 / 483

页数：7

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