Targeted Molecular Therapies in Allergy and Rhinology

被引：21

作者：

Damask, Cecelia C. ^{[1
]}

Ryan, Matthew W. ^{[2
]}

Casale, Thomas B. ^{[3
]}

Castro, Mario ^{[4
]}

Franzese, Christine B. ^{[5
]}

Lee, Stella E. ^{[6
]}

Levy, Joshua M. ^{[7
]}

Lin, Sandra Y. ^{[8
]}

Lio, Peter A. ^{[9
]}

Peters, Anju T. ^{[9
]}

Platt, Michael P. ^{[10
]}

White, Andrew A. ^{[11
]}

机构：

[1] Univ Cent Florida, 795 Primera Blvd,Ste 1031, Lake Mary, FL 32746 USA

[2] UT Southwestern Med Ctr, Dallas, TX USA

[3] Univ S Florida, Tampa, FL 33620 USA

[4] Univ Kansas, Med Ctr, Kansas City, KS 66103 USA

[5] Univ Missouri, Med Ctr, Columbia, MO USA

[6] Univ Pittsburgh, Pittsburgh, PA USA

[7] Emory Med, Atlanta, GA USA

[8] Johns Hopkins Med, Baltimore, MD USA

[9] Northwestern Med, Chicago, IL USA

[10] Boston Med Ctr, Boston, MA USA

[11] Scripps Clin, La Jolla, CA 92037 USA

来源：

OTOLARYNGOLOGY-HEAD AND NECK SURGERY | 2021年 / 164卷 / 1_SUPPL期

关键词：

biologics; biologic agent; anti-IgE; anti-IL-5; anti-IL-4; anti-IL-13; anti-TSLP; omalizumab; mepolizumab; reslizumab; benralizumab; dupilumab; tezepelumab; T2; inflammation; asthma; allergic asthma; eosinophilic asthma; chronic rhinosinusitis with nasal polyposis; atopic dermatitis; chronic spontaneous urticaria; eosinophilic granulomatosis with polyangiitis; aspirin-exacerbated respiratory disease; eosinophilia; unified airway;

D O I：

10.1177/0194599820965233

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Biologic agents, monoclonal antibodies that target highly-specific molecular pathways of inflammation, are becoming integrated into care pathways for multiple disorders that are relevant in otolaryngology and allergy. These conditions share common inflammatory mechanisms of so-called Type 2 inflammation with dysregulation of immunoglobulin E production and eosinophil and mast cell degranulation leading to tissue damage. Biologic agents are now available for the treatment of chronic rhinosinusitis with nasal polyps (CRSwNP), asthma, eosinophilic granulomatosis with polyangiitis (EGPA), atopic dermatitis (AD), and chronic spontaneous urticaria (CSU). This paper summarizes the diagnosis and management of these conditions and critically reviews the clinical trial data that has led to regulatory approval of biologic agents for these conditions.

引用

页码：S1 / S21

页数：21

共 123 条

[1] Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials [J].

Bachert, Claus ;

Han, Joseph K. ;

Desrosiers, Martin ;

Hellings, Peter W. ;

Amin, Nikhil ;

Lee, Stella E. ;

Mullol, Joaquim ;

Greos, Leon S. ;

Bosso, John V. ;

Laidlaw, Tanya M. ;

Cervin, Anders U. ;

Maspero, Jorge F. ;

Hopkins, Claire ;

Olze, Heidi ;

Canonica, G. Walter ;

Paggiaro, Pierluigi ;

Cho, Seong H. ;

Fokkens, Wytske J. ;

Fujieda, Shigeharu ;

Zhang, Mei ;

Lu, Xin ;

Fan, Chunpeng ;

Draikiwicz, Steven ;

Kamat, Siddhesh A. ;

Khan, Asif ;

Pirozzi, Gianluca ;

Patel, Naimish ;

Graham, Neil M. H. ;

Ruddy, Marcella ;

Staudinger, Heribert ;

Weinreich, David ;

Stahl, Neil ;

Yancopoulos, George D. ;

Mannent, Leda P. .

LANCET, 2019, 394 (10209) :1638-1650

[2] A Randomized Phase 3 Study, Sinus-52, Evaluating the Efficacy and Safety of Dupilumab in Patients with Severe Chronic Rhinosinusitis with Nasal Polyps [J].

Bachert, Claus ;

Desrosiers, Martin ;

Mullol, Joaquim ;

Hellings, Peter W. ;

Cervin, Anders ;

Sher, Lawrence ;

Bosso, John V. ;

Lee, Stella E. ;

Maspero, Jorge F. ;

Fujieda, Shigeharu ;

Matsune, Shoji ;

Lu, Xin ;

Fan, Chunpeng ;

Draikiwicz, Steven ;

Amin, Nikhil ;

Kamat, Siddhesh ;

Khan, Asif ;

Pirozzi, Gianluca ;

Graham, Neil M. H. ;

Ruddy, Marcella ;

Staudinger, Heribert ;

Mannent, Leda P. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2019, 143 (02) :AB433-AB433

[3] Effect of Subcutaneous Dupilumab on Nasal Polyp Burden in Patients With Chronic Sinusitis and Nasal Polyposis A Randomized Clinical Trial [J].

Bachert, Claus ;

Mannent, Leda ;

Naclerio, Robert M. ;

Mullol, Joaquim ;

Ferguson, Berrylin J. ;

Gevaert, Philippe ;

Hellings, Peter ;

Jiao, Lixia ;

Wang, Lin ;

Evans, Robert R. ;

Pirozzi, Gianluca ;

Graham, Neil M. ;

Swanson, Brian ;

Hamilton, Jennifer D. ;

Radin, Allen ;

Gandhi, Namita A. ;

Stahl, Neil ;

Yancopoulos, George D. ;

Sutherland, E. Rand .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2016, 315 (05) :469-479

[4] Reduced need for surgery in severe nasal polyposis with mepolizumab: Randomized trial [J].

Bachert, Claus ;

Sousa, Ana R. ;

Lund, Valerie J. ;

Scadding, Glenis K. ;

Gevaert, Philippe ;

Nasser, Shuaib ;

Durham, Stephen R. ;

Cornet, Marjolein E. ;

Kariyawasam, Harsha H. ;

Gilbert, Jane ;

Austin, Daren ;

Maxwell, Aoife C. ;

Marshall, Richard P. ;

Fokkens, Wytske J. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2017, 140 (04) :1024-+

[5] A Critical Evaluation of Anti-IL-13 and Anti-IL-4 Strategies in Severe Asthma [J].

Bagnasco, Diego ;

Ferrando, Matteo ;

Varricchi, Gilda ;

Passalacqua, Giovanni ;

Canonica, Giorgio Walter .

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2016, 170 (02) :122-131

[6] The Asthma Control Questionnaire as a clinical trial endpoint: past experience and recommendations for future use [J].

Barnes, P. J. ;

Casale, T. B. ;

Dahl, R. ;

Pavord, I. D. ;

Wechsler, M. E. .

ALLERGY, 2014, 69 (09) :1119-1140

[7] Analysis of Comorbidities and Objective Parameters in Refractory Chronic Rhinosinusitis [J].

Batra, Pete S. ;

Tong, Liyue ;

Citardi, Martin J. .

LARYNGOSCOPE, 2013, 123 :S1-S11

[8] Outcome analysis of endoscopic sinus surgery in patients with nasal polyps and asthma [J].

Batra, PS ;

Kern, RC ;

Tripathi, A ;

Conley, DB ;

Ditto, AM ;

Haines, GK ;

Yarnold, PR ;

Grammar, L .

LARYNGOSCOPE, 2003, 113 (10) :1703-1706

[9] Omalizumab-induced reductions in mast cell FcεRI expression and function [J].

Beck, LA ;

Marcotte, GV ;

MacGlashan, D ;

Togias, A ;

Saini, S .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2004, 114 (03) :527-530

[10] Oral Glucocorticoid-Sparing Effect of Mepolizumab in Eosinophilic Asthma [J].

Bel, Elisabeth H. ;

Wenzel, Sally E. ;

Thompson, Philip J. ;

Prazma, Charlene M. ;

Keene, Oliver N. ;

Yancey, Steven W. ;

Ortega, Hector G. ;

Pavord, Ian D. .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (13) :1189-1197

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