Signal transduction to hypoxia-inducible factor 1

被引：704

作者：

Semenza, GL ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Inst Med Genet, Baltimore, MD 21287 USA

来源：

BIOCHEMICAL PHARMACOLOGY | 2002年 / 64卷 / 5-6期

关键词：

growth factor; MAP kinase; phosphatidylinositol; 3-kinase; prolyl hydroxylase; receptor tyrosine kinase;

D O I：

10.1016/S0006-2952(02)01168-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Hypoxia-inducible factor I (HIF-1) is a transcriptional activator that functions as a master regulator of O-2 homeostasis. HIF-1 target,genes encode proteins that increase O-2 delivery and mediate adaptive responses to O-2 deprivation. HIF-1 activity is regulated by the cellular O-2 concentration and by the major growth factor-stimulated signal transduction pathways. In human cancer cells, both intratumoral hypoxia and genetic alterations affecting signal transduction pathways lead to increased HIF-1 activity, which promotes angiogenesis, metabolic adaptation, and other critical aspects of tumor progression. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：993 / 998

页数：6

共 67 条

[1]

Aebersold DM, 2001, CANCER RES, V61, P2911

[2] Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1 [J].

Bhattacharya, S ;

Michels, CL ;

Leung, MK ;

Arany, ZP ;

Kung, AL ;

Livingston, DM .

GENES & DEVELOPMENT, 1999, 13 (01) :64-75

[3]

Birner P, 2000, CANCER RES, V60, P4693

[4]

Birner P, 2001, CLIN CANCER RES, V7, P1661

[5]

Birner P, 2001, CANCER, V92, P165, DOI 10.1002/1097-0142(20010701)92:1<165::AID-CNCR1305>3.0.CO

[6]

2-F

[7] Levels of hypoxia-inducible factor-1α during breast carcinogenesis [J].

Bos, R ;

Zhong, H ;

Hanrahan, CF ;

Mommers, ECM ;

Semenza, GL ;

Pinedo, HM ;

Abeloff, MD ;

Simons, JW ;

van Diest, PJ ;

van der Wall, E .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2001, 93 (04) :309-314

[8] A conserved family of prolyl-4-hydroxylases that modify HIF [J].

Bruick, RK ;

McKnight, SL .

SCIENCE, 2001, 294 (5545) :1337-1340

[9] Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia [J].

Bruick, RK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (16) :9082-9087

[10] Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFβ3 [J].

Caniggia, I ;

Mostachfi, H ;

Winter, J ;

Gassmann, M ;

Lye, SJ ;

Kuliszewski, M ;

Post, M .

JOURNAL OF CLINICAL INVESTIGATION, 2000, 105 (05) :577-587

← 1 2 3 4 5 6 7 →