Lateral-flow particle filtration and separation with multilayer microfluidic channels

被引：3

作者：

Kim, Hyun Chul ^{[1
]}

Park, Jaewon ^{[1
]}

Cho, Younghak ^{[2
]}

Park, Hyunsoo ^{[1
]}

Han, Arum ^{[1
]}

Cheng, Xing ^{[1
]}

机构：

[1] Texas A&M Univ, Dept Elect & Comp Engn, College Stn, TX 77843 USA

[2] Seoul Natl Univ Technol, Sch Mech Design & Automat Engn, Seoul 139743, South Korea

来源：

JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B | 2009年 / 27卷 / 06期

关键词：

flow separation; fractionation; microchannel flow; suspensions; FRACTIONATION; DEVICES; NANOTECHNOLOGY; CLASSIFICATION; MICROCHANNEL; DISPLACEMENT; CELLS; SIZE;

D O I：

10.1116/1.3258155

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

Separating particles from a suspension and sorting particles into different size ranges are important to many chemical, biological, and bioengineering applications. In this article, a novel lateral-flow particle separation device is presented for continuous particle fractionation from suspensions. This device is based on three-dimensional multilayer poly(dimethylsiloxane) microchannels, which can be fabricated by high-yield and low-cost molding and transfer-bonding techniques. By varying the dimensions of the microchannels in each layer, particles in a suspension can be fractionated into specific layers based on their sizes. Particle separation is successfully achieved in sorting polystyrene microbeads of 1, 10, and 45 mu m in diameter into different layers. The yield and selectivity of particle separation can be controlled by device geometries such as channel width and length. This novel continuous-flow particle filtration and separation device is expected to find applications in micrototal analysis systems due to its simple fabrication steps, low cost, and capability of particle separation in a deterministic fashion.

引用

页码：3115 / 3119

页数：5

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