Total Synthesis of the Anti-Apoptotic Agents Iso- and Bongkrekic Acids

被引：78

作者：

Francais, Antoine ^{[1
]}

Leyva, Antonio ^{[1
]}

Etxebarria-Jardi, Gorka ^{[1
]}

Ley, Steven V. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 02期

基金：

英国工程与自然科学研究理事会;

关键词：

CROSS-COUPLING REACTIONS; ISOBONGKREKIC ACID; NATURAL-PRODUCT; STRATEGY; TRANSLOCATION; MITOCHONDRIA; CYCLIZATION; INHIBITOR; OXIDATION; ALCOHOLS;

D O I：

10.1021/ol902676t

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first convergent total synthesis of isobongkrekic acid is reported Involving three different stereospecific palladium cross-couplings for the formation of the diene units. Access to bongkrekic acid by this route Is also demonstrated. These syntheses involve the formation of several potentially general building blocks.

引用

页码：340 / 343

页数：4

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