A novel target for combination immunotherapy in pancreatic cancer: IL-1β mediates immunosuppression in the tumour microenvironment

被引：9

作者：

Winograd, Rafael ^{[1
,2
]}

Simeone, Diane M. ^{[2
,3
,4
]}

Bar-Sagi, Dafna ^{[5
]}

机构：

[1] NYU Langone Hlth, Dept Hematol & Oncol, New York, NY USA

[2] NYU Langone Hlth, Perlmutter Canc Ctr, New York, NY USA

[3] NYU Langone Hlth, Dept Surg, New York, NY USA

[4] NYU Langone Hlth, Dept Pathol, New York, NY USA

[5] NYU, Grossman Sch Med, Dept Biochem & Mol Pharmacol, New York, NY USA

来源：

BRITISH JOURNAL OF CANCER | 2021年 / 124卷 / 11期

关键词：

SUPPRESSOR-CELLS; INFLAMMATION;

D O I：

10.1038/s41416-021-01303-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Immune checkpoint blockade (ICB) has demonstrated efficacy in multiple cancers, offering the potential of long-term disease control not achievable with cytotoxic or targeted therapies. However, the field has not yet achieved the crucial next steps - the expansion of the response rate and achievement of clinical efficacy in so-called "cold tumours". Mechanistic studies of tumour-type specific immunosuppressive pathways can reveal underlying biological hurdles to immunotherapy and offer new therapeutic insights. Our finding that tumour-derived IL-1 beta mediates immunosuppression in pancreatic cancer has precipitated a new clinical trial.

引用

页码：1754 / 1756

页数：3

共 10 条

[1] DIVERSITY AND BIOLOGY OF CANCER-ASSOCIATED FIBROBLASTS [J].

Biffi, Giulia ;

Tuveson, David A. .

PHYSIOLOGICAL REVIEWS, 2021, 101 (01) :147-176

[2] Inflammation induces myeloid-derived suppressor cells that facilitate tumor progression [J].

Bunt, SK ;

Sinha, P ;

Clements, VK ;

Leips, J ;

Ostrand-Rosenberg, S .

JOURNAL OF IMMUNOLOGY, 2006, 176 (01) :284-290

[3] The Role of IL-1β in the Early Tumor Cell-Induced Angiogenic Response [J].

Carmi, Yaron ;

Dotan, Shahar ;

Rider, Peleg ;

Kaplanov, Irena ;

White, Malka R. ;

Baron, Rona ;

Abutbul, Shai ;

Huszar, Monica ;

Dinarello, Charles A. ;

Apte, Ron N. ;

Voronov, Elena .

JOURNAL OF IMMUNOLOGY, 2013, 190 (07) :3500-3509

[4] Tumor Cell-Derived IL1β Promotes Desmoplasia and Immune Suppression in Pancreatic Cancer [J].

Das, Shipra ;

Shapiro, Beny ;

Vucic, Emily A. ;

Vogt, Sandra ;

Bar-Sagi, Dafna .

CANCER RESEARCH, 2020, 80 (05) :1088-1101

[5] IL-1 and IL-1 regulatory pathways in cancer progression and therapy [J].

Mantovani, Alberto ;

Barajon, Isabella ;

Garlanda, Cecilia .

IMMUNOLOGICAL REVIEWS, 2018, 281 (01) :57-61

[6] Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial [J].

Ridker, Paul M. ;

MacFadyen, Jean G. ;

Thuren, Tom ;

Everett, Brendan M. ;

Libby, Peter ;

Glynn, Robert J. .

LANCET, 2017, 390 (10105) :1833-1842

[7] Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes [J].

Riquelme, Erick ;

Zhang, Yu ;

Zhang, Liangliang ;

Montiel, Maria ;

Zoltan, Michelle ;

Dong, Wenli ;

Quesada, Pompeyo ;

Sahin, Ismet ;

Chandra, Vidhi ;

San Lucas, Anthony ;

Scheet, Paul ;

Xu, Hanwen ;

Hanash, Samir M. ;

Feng, Lei ;

Burks, Jared K. ;

Do, Kim-Anh ;

Peterson, Christine B. ;

Nejman, Deborah ;

Tzeng, Ching-Wei D. ;

Kim, Michael P. ;

Sears, Cynthia L. ;

Ajami, Nadim ;

Petrosino, Joseph ;

Wood, Laura D. ;

Maitra, Anirban ;

Straussman, Ravid ;

Katz, Matthew ;

White, James Robert ;

Jenq, Robert ;

Wargo, Jennifer ;

McAllister, Florencia .

CELL, 2019, 178 (04) :795-+

[8] The future of immune checkpoint therapy [J].

Sharma, Padmanee ;

Allison, James P. .

SCIENCE, 2015, 348 (6230) :56-61

[9] Overexpression of Interleukin-1β Induces Gastric Inflammation and Cancer and Mobilizes Myeloid-Derived Suppressor Cells in Mice [J].

Tu, Shuiping ;

Bhagat, Govind ;

Cui, Guanglin ;

Takaishi, Shigeo ;

Kurt-Jones, Evelyn A. ;

Rickman, Barry ;

Betz, Kelly S. ;

Penz-Oesterreicher, Melitta ;

Bjorkdahl, Olle ;

Fox, James G. ;

Wang, Timothy C. .

CANCER CELL, 2008, 14 (05) :408-419

[10] Induction of T-cell Immunity Overcomes Complete Resistance to PD-1 and CTLA-4 Blockade and Improves Survival in Pancreatic Carcinoma [J].

Winograd, Rafael ;

Byrne, Katelyn T. ;

Evans, Rebecca A. ;

Odorizzi, Pamela M. ;

Meyer, Anders R. L. ;

Bajor, David L. ;

Clendenin, Cynthia ;

Stanger, Ben Z. ;

Furth, Emma E. ;

Wherry, E. John ;

Vonderheide, Robert H. .

CANCER IMMUNOLOGY RESEARCH, 2015, 3 (04) :399-411

← 1 →