Optimizing the spatial resolution of photonic crystal label-free imaging

被引：22

作者：

Block, Ian D. ^{[1
]}

Mathias, Patrick C. ^{[2
]}

Jones, Sarah I. ^{[3
]}

Vodkin, Lila O. ^{[3
]}

Cunningham, Brian T. ^{[1
]}

机构：

[1] Univ Illinois, Dept Elect & Comp Engn, Urbana, IL 61801 USA

[2] Univ Illinois, Dept Bioengn, Urbana, IL 61801 USA

[3] Univ Illinois, Dept Crop Sci, Urbana, IL 61801 USA

来源：

APPLIED OPTICS | 2009年 / 48卷 / 34期

关键词：

BIOMOLECULAR INTERACTIONS; BIOSENSORS; CYTOTOXICITY; MICROARRAYS;

D O I：

10.1364/AO.48.006567

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

A theory is derived to describe the relationship between photonic crystal (PC) label-free imaging resolution and PC resonance spectral linewidth and location. PCs are fabricated and patterned with a resolution standard photomask in order to verify this relationship experimentally. Two distinct linear resolutions of <1 mu m and 3.5 mu m are demonstrated in orthogonal directions on a single device, where the former is limited by the imaging system optics and the latter is constrained by finite resonant mode propagation. In order to illustrate the utility of improved design control, the spectral response of a PC is optimized for label-free imaging of immobilized DNA capture spots on a microarray. (C) 2009 Optical Society of America

引用

页码：6567 / 6574

页数：8

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