Kynurenic acid amides as novel NR2B selective NMDA receptor antagonists

被引：35

作者：

Borza, Istvan ^{[1
]}

Kolok, Sandor ^{[1
]}

Galgoczy, Kornel ^{[1
]}

Gere, Aniko ^{[1
]}

Horvath, Csilla ^{[1
]}

Farkas, Sandor ^{[1
]}

Greiner, Istvan ^{[1
]}

Domany, Gyorgy ^{[1
]}

机构：

[1] Gedeon Richter Chem Works Ltd, H-1475 Budapest 10, Hungary

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 02期

关键词：

NR2B antagonist; kynurenic acid amide;

D O I：

10.1016/j.bmcl.2006.10.033

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel series of kynurenic acid amides, ring-enlarged derivatives of indole-2-carboxamides, was prepared and identified as in vivo active NR2B subtype selective NMDA receptor antagonists. The synthesis and SAR studies are discussed. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：406 / 409

页数：4

共 16 条

[1] Indole-2-carboxamides as novel NR2B selective NMDA receptor antagonists
Borza, I
Kolok, S
Gere, A
Agai-Csongor, É
Agai, B
Tárkányi, G
Horváth, C
Barta-Szalai, G
Bozó, É
Kiss, C
Bielik, A
Nagy, J
Farkas, S
Domány, G
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2003, 13 (21) : 3859 - 3861
[2] BORZA I, 2006, Patent No. 2006010967
[3] Benzimidazole-2-carboxamides as novel NR2B selective NMDA receptor antagonists
Borza, Istvan
Kolok, Sandor
Gere, Aniko
Nagy, Jozsef
Fodor, Laszlo
Galgoczy, Kornel
Fetter, Jozsef
Bertha, Ferenc
Agai, Bela
Horvath, Csilla
Farkas, Sandor
Domany, Gyorgy
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (17) : 4638 - 4640
[4] NR2B selective NMDA antagonists:: The evolution of the ifenprodil-type pharmaeophore
Borza, Istvan
Domany, Gyorgy
[J]. CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2006, 6 (07) : 687 - 695
[5] The NMDA receptor NR2B subunit: A valid therapeutic target for multiple CNS pathologies
Chazot, PL
[J]. CURRENT MEDICINAL CHEMISTRY, 2004, 11 (03) : 389 - 396
[6] Chenard BL, 1999, CURR PHARM DESIGN, V5, P381
[7] Fischer G, 1997, J PHARMACOL EXP THER, V283, P1285
[8] FORMALIN TEST IN MICE, A USEFUL TECHNIQUE FOR EVALUATING MILD ANALGESICS
HUNSKAAR, S
FASMER, OB
HOLE, K
[J]. JOURNAL OF NEUROSCIENCE METHODS, 1985, 14 (01) : 69 - 76
[9] KYNURENIC ACID-DERIVATIVES INHIBIT THE BINDING OF NERVE GROWTH-FACTOR (NGF) TO THE LOW-AFFINITY P75 NGF RECEPTOR
JAEN, JC
LABORDE, E
BUCSH, RA
CAPRATHE, BW
SORENSON, RJ
FERGUS, J
SPIEGEL, K
MARKS, J
DICKERSON, MR
DAVIS, RE
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (22) : 4439 - 4445
[10] NR2B subtype-selective NMDA receptor antagonists: 2001-2004
McCauley, JA
[J]. EXPERT OPINION ON THERAPEUTIC PATENTS, 2005, 15 (04) : 389 - 407

← 1 2 →