Combined Effect of Mediterranean Diet and Aerobic Exercise on Weight Loss and Clinical Status in Obese Symptomatic Patients with Hypertrophic Cardiomyopathy

被引：24

作者：

Limongelli, Giuseppe ^{[1
,2
,3
]}

Monda, Emanuele ^{[1
]}

D' Aponte, Antonell ^{[4
,5
]}

Caiazza, Martina ^{[1
]}

Rubino, Marta ^{[1
]}

Esposito, Augusto ^{[1
]}

Palmiero, Giuseppe ^{[1
,4
,5
]}

Moscarella, Elisabetta ^{[1
]}

Messina, Giovanni ^{[4
,5
]}

Calabro, Paolo ^{[1
]}

Scudiero, Olga ^{[6
,7
,8
]}

Pacileo, Giuseppe ^{[1
]}

Monda, Marcellino ^{[4
,5
]}

Bossone, Eduardo ^{[9
]}

Day, Sharlene M. ^{[10
]}

Olivotto, Iacopo ^{[11
,12
]}

机构：

[1] Univ Campania Luigi Vanvitelli, Dept Translat Med Sci, Via L Bianchi, I-80131 Naples, Italy

[2] UCL, Inst Cardiovasc Sci, Grower St, London WC1E 6DD, England

[3] St Bartholomews Hosp, Grower St, London WC1E 6DD, England

[4] Univ Campania Luigi Vanvitelli, Sect Human Physiol, Dept Expt Med, Via Santa Maria Costantinopoli, I-80138 Naples, Italy

[5] Univ Campania Luigi Vanvitelli, Unit Dietet & Sports Med, Via Santa Maria Costantinopoli, I-80138 Naples, Italy

[6] Univ Naples Federico II, Dept Mol Med & Med Biotechnol, Via G Salvatore, I-80138 Naples, Italy

[7] CEINGE Adv Biotechnol, Via G Salvatore, I-80138 Naples, Italy

[8] Univ Naples Federico II, Task Force Microbiome Studies, Via G Salvatore, I-80138 Naples, Italy

[9] Antonio Cardarelli Hosp, Div Cardiol, Via A Cardarelli, I-80131 Naples, Italy

[10] Univ Michigan, Dept Internal Med, 500 S State St, Ann Arbor, MI 48109 USA

[11] Careggi Univ Hosp, Cardiomyopathy Unit, I-50134 Florence, Italy

[12] Careggi Univ Hosp, Genet Unit, I-50134 Florence, Italy

来源：

HEART FAILURE CLINICS | 2021年 / 17卷 / 02期

关键词：

Hypertrophic cardiomyopathy; Obesity; Mediterranean diet; Aerobic exercise; VENTRICULAR DIASTOLIC FUNCTION; EUROPEAN ASSOCIATION; TASK-FORCE; MANAGEMENT; DIAGNOSIS; GUIDELINES; SOCIETY; ESC;

D O I：

10.1016/j.hfc.2021.01.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We evaluated the impact of weight loss (WL) using a Mediterranean diet and mild-to-moderate–intensity aerobic exercise program, on clinical status of obese, symptomatic patients with hypertrophic cardiomyopathy (HCM). Compared with nonresponders, responders showed a significant reduction of left atrial diameter, left atrial volume index (LAVI), E/Eʹaverage, pulmonary artery systolic pressure (PASP), and a significant increase in VO2max (%) and peak workload. Body mass index changes correlated with reduction in left atrial diameter, LAVI, E/Eʹaverage, PASP, and increase of VO2max (mL/Kg/min), VO2max (%), peak workload. Mediterranean diet and aerobic exercise is associated with clinical-hemodynamic improvement in obese symptomatic HCM patients. © 2021 Elsevier Inc.

引用

页码：303 / 313

页数：11

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