Ligand-Dependent-Controlled Copper-Catalyzed Regio- and Stereoselective Silaboration of Alkynes

被引：35

作者：

Zhao, Meng ^{[1
]}

Shan, Cui-Cui ^{[1
]}

Wang, Zi-Lu ^{[1
]}

Yang, Chao ^{[1
]}

Fu, Yao ^{[1
]}

Xuo, Yun-He ^{[1
]}

机构：

[1] Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 15期

基金：

中国国家自然科学基金;

关键词：

CONJUGATE SILYL TRANSFER; SI-B BOND; CROSS-COUPLING REACTIONS; NUCLEOPHILIC SILICON; TERMINAL ALKYNES; MULTISUBSTITUTED OLEFINS; REGIOSELECTIVE ADDITION; ALLYLIC SUBSTITUTION; ALLENES; VINYLSILANES;

D O I：

10.1021/acs.orglett.9b02160

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A copper-catalyzed highly regio- and stereoselective silaboration of alkynes was developed. In this work, direct cis-difunctionalization of alkynes was realized with silaboronate reagent and copper catalyst in aprotic solvents. The regiodivergent silaborations were controlled by tuning the copper catalysts and phosphine ligands used in reactions. This protocol provides an efficient and practical method to synthesize the multisubstituted functionalized alkenes with specific stereoselectivity.

引用

页码：6016 / 6020

页数：5

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