sORF-Encoded MicroPeptides: New players in inflammation, metabolism, and precision medicine

被引：36

作者：

Chen, Ying ^{[1
]}

Ho, Lena ^{[1
,2
,3
]}

Tergaonkar, Vinay ^{[1
,4
]}

机构：

[1] ASTAR, Inst Mol & Cell Biol IMCB, Singapore 138673, Singapore

[2] Duke NUS Grad Sch, Cardiovasc Metab Disorders Program, Singapore, Singapore

[3] ASTAR, Inst Med Biol, Singapore, Singapore

[4] Natl Univ Singapore NUS, Yong Loo Lin Sch Med, Dept Pathol, Singapore 117597, Singapore

来源：

CANCER LETTERS | 2021年 / 500卷

基金：

新加坡国家研究基金会;

关键词：

ncRNA; Small peptides; SEPs; Inflammation; NEURONAL CELL-DEATH; NONCODING RNA; MITOCHONDRIAL MICROPEPTIDE; GROWTH-FACTOR; HUMANIN; PEPTIDES; CALCIUM; HOMEOSTASIS; MICROPROTEIN; TRANSLATION;

D O I：

10.1016/j.canlet.2020.10.038

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Significant technological advances have enabled the discovery and identification of a new class of molecules, micropeptides or small ORF encoded peptides (SEPs) within non-coding RNAs (ncRNAs). As ncRNAs are well known to be transcriptionally silent, the discovery of SEPs implies that many ncRNAs are misannotated or play both coding and non-coding functions. SEPs have reportedly diverse regulatory roles in embryogenesis, myogenesis, inflammation, diseases, and cancer. SEPs appearing in different subcellular compartments show distinct functions. In this review, we summarized the functions of SEPs that have been characterized thus far. As SEPs are amenable to therapeutic development as biologics, understanding their underlying functions will provide novel targets for the treatment of inflammatory or metabolic disorders.

引用

页码：263 / 270

页数：8

共 83 条

[1] Specificity of 14-3-3 isoform dimer interactions and phosphorylation [J].

Aitken, A ;

Baxter, H ;

Dubois, T ;

Clokie, S ;

Mackie, S ;

Mitchell, K ;

Peden, A ;

Zemlickova, E .

BIOCHEMICAL SOCIETY TRANSACTIONS, 2002, 30 :351-360

[2] Quantitative assessment of telomerase components in cancer cell lines [J].

Akincilar, Semih Can ;

Low, Kee Chung ;

Liu, Chia Yi ;

Yan, Ting Dong ;

Oji, Asami ;

Ikawa, Masahito ;

Li, Shang ;

Tergaonkar, Vinay .

FEBS LETTERS, 2015, 589 (09) :974-984

[3] Widespread control of calcium signaling by a family of SERCA-inhibiting micropeptides [J].

Anderson, Douglas M. ;

Makarewich, Catherine A. ;

Anderson, Kelly M. ;

Shelton, John M. ;

Bezprozvannaya, Svetlana ;

Bassel-Duby, Rhonda ;

Olson, Eric N. .

Science Signaling, 2016, 9 (457)

[4] A Micropeptide Encoded by a Putative Long Noncoding RNA Regulates Muscle Performance [J].

Anderson, Douglas M. ;

Anderson, Kelly M. ;

Chang, Chi-Lun ;

Makarewich, Catherine A. ;

Nelson, Benjamin R. ;

McAnally, John R. ;

Kasaragod, Prasad ;

Shelton, John M. ;

Liou, Jen ;

Bassel-Duby, Rhonda ;

Olson, Eric N. .

CELL, 2015, 160 (04) :595-606

[5] Long noncoding RNAs are rarely translated in two human cell lines [J].

Banfai, Balazs ;

Jia, Hui ;

Khatun, Jainab ;

Wood, Emily ;

Risk, Brian ;

Gundling, William E., Jr. ;

Kundaje, Anshul ;

Gunawardena, Harsha P. ;

Yu, Yanbao ;

Xie, Ling ;

Krajewski, Krzysztof ;

Strahl, Brian D. ;

Chen, Xian ;

Bickel, Peter ;

Giddings, Morgan C. ;

Brown, James B. ;

Lipovich, Leonard .

GENOME RESEARCH, 2012, 22 (09) :1646-1657

[6] Mitochondrial protein import: from transport pathways to an integrated network [J].

Becker, Thomas ;

Boettinger, Lena ;

Pfanner, Nikolaus .

TRENDS IN BIOCHEMICAL SCIENCES, 2012, 37 (03) :85-91

[7] Calcium signalling: Dynamics, homeostasis and remodelling [J].

Berridge, MJ ;

Bootman, MD ;

Roderick, HL .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2003, 4 (07) :517-529

[8] A Mitochondrial Micropeptide Is Required for Activation of the Nlrp3 Inflammasome [J].

Bhatta, Ankit ;

Atianand, Maninjay ;

Jiang, Zhaozhao ;

Crabtree, Juliet ;

Blin, Juliana ;

Fitzgerald, Katherine A. .

JOURNAL OF IMMUNOLOGY, 2020, 204 (02) :428-437

[9] Control of muscle formation by the fusogenic micropeptide myomixer [J].

Bi, Pengpeng ;

Ramirez-Martinez, Andres ;

Li, Hui ;

Cannavino, Jessica ;

McAnally, John R. ;

Shelton, John M. ;

Sanchez-Ortiz, Efrain ;

Bassel-Duby, Rhonda ;

Olson, Eric N. .

SCIENCE, 2017, 356 (6335) :323-327

[10] MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins [J].

Calvo, Sarah E. ;

Clauser, Karl R. ;

Mootha, Vamsi K. .

NUCLEIC ACIDS RESEARCH, 2016, 44 (D1) :D1251-D1257

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