EZH2 inactivation in RAS-driven myeloid neoplasms hyperactivates RAS-signaling and increases MEK inhibitor sensitivity

被引：4

作者：

Berg, Johannes Lorenz ^{[1
]}

Perfler, Bianca ^{[1
]}

Hatzl, Stefan ^{[1
]}

Uhl, Barbara ^{[1
]}

Reinisch, Andreas ^{[1
]}

Pregartner, Gudrun ^{[2
]}

Berghold, Andrea ^{[2
]}

Penz, Thomas ^{[3
]}

Schuster, Michael ^{[3
]}

Geissler, Klaus ^{[4
,5
]}

Prokesch, Andreas ^{[6
,7
,8
]}

Mueller-Tidow, Carsten ^{[9
]}

Hoefler, Gerald ^{[10
]}

Kashofer, Karl ^{[10
]}

Woelfler, Albert ^{[1
]}

Sill, Heinz ^{[1
]}

Caraffini, Veronica ^{[1
,11
]}

Zebisch, Armin ^{[1
,12
]}

机构：

[1] Med Univ Graz, Div Hematol, Graz, Austria

[2] Med Univ Graz, Inst Med Informat Stat & Documentat, Graz, Austria

[3] Austrian Acad Sci, CeMM Res Ctr Mol Med, Vienna, Austria

[4] Hosp Hietzing, Med Dept Hematol Oncol & Palliat Med 5, Vienna, Austria

[5] Sigmund Freud Univ, Vienna, Austria

[6] Med Univ Graz, Gottfried Schatz Res Ctr Cell Signaling Metab & A, Graz, Austria

[7] Med Univ Graz, Div Cell Biol Histol & Embryol, Graz, Austria

[8] BioTechMed Graz, Graz, Austria

[9] Univ Hosp Heidelberg, Heidelberg, Germany

[10] Med Univ Graz, Diagnost & Res Inst Pathol, Graz, Austria

[11] Univ Cambridge, MRC Canc Unit, Hutchison MRC Res Ctr, Cambridge, England

[12] Med Univ Graz, Div Pharmacol, Otto Loewi Res Ctr Vasc Biol Immunol & Inflammat, Graz, Austria

来源：

LEUKEMIA | 2021年 / 35卷 / 05期

基金：

奥地利科学基金会;

关键词：

D O I：

10.1038/s41375-021-01161-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

[No abstract available]

引用

页码：1521 / 1526

页数：6

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