Charcot-Leyden crystal protein/galectin-10 is a surrogate biomarker of eosinophilic airway inflammation in asthma

被引：30
|
作者：
Nyenhuis, Sharmilee M. [1 ]
Alumkal, Preeth [2 ]
Du, Jian [2 ]
Maybruck, Brian T. [2 ]
Vinicky, Mark [1 ]
Ackerman, Steven J. [1 ,2 ]
机构：
[1] Univ Illinois, Dept Med, Chicago, IL 60612 USA
[2] Univ Illinois, Dept Biochem & Mol Genet, Chicago, IL 60612 USA
来源：
BIOMARKERS IN MEDICINE | 2019年 / 13卷 / 09期
关键词：
asthma; biomarker; eosinophil; sputum; MAJOR BASIC-PROTEIN; INDUCED SPUTUM; CATIONIC PROTEIN; PHENOTYPES; GALECTIN-10; PEROXIDASE; GRANULE; LYSOPHOSPHOLIPASE; EXACERBATIONS; DEGRANULATION;
D O I：
10.2217/bmm-2018-0280
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Eosinophilic asthma is associated with more exacerbations and differential responses to treatment. The aim of this study was to assess if CLC/Gal-10 and MBP-1 are surrogate biomarkers of eosinophilic inflammation in asthma. Methods & results: Sputum induction was performed in patients with asthma and in healthy controls. Sputum analysis revealed higher (p < 0.001) levels of CLC/Gal-10 and MBP-1 in asthmatics versus healthy controls. CLC/Gal-10 levels were highly correlated (r(s) = 0.74; p < 0.001) with sputum eosinophils; MBP-1 approached significance (r = 0.44; p = 0.07). Conclusion: Increased CLC/Gal-10 andMBP-1 levels in the sputum were strongly correlated with sputum eosinophils in patients with asthma. CLC/Gal-10 and MBP-1 may be useful biomarkers for differentiation of eosinophilic airway inflammation in asthma.
引用
收藏
页码：715 / 724
页数：10
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