Charcot-Leyden crystal protein/galectin-10 is a surrogate biomarker of eosinophilic airway inflammation in asthma

被引：30

作者：

Nyenhuis, Sharmilee M. ^{[1
]}

Alumkal, Preeth ^{[2
]}

Du, Jian ^{[2
]}

Maybruck, Brian T. ^{[2
]}

Vinicky, Mark ^{[1
]}

Ackerman, Steven J. ^{[1
,2
]}

机构：

[1] Univ Illinois, Dept Med, Chicago, IL 60612 USA

[2] Univ Illinois, Dept Biochem & Mol Genet, Chicago, IL 60612 USA

来源：

BIOMARKERS IN MEDICINE | 2019年 / 13卷 / 09期

关键词：

asthma; biomarker; eosinophil; sputum; MAJOR BASIC-PROTEIN; INDUCED SPUTUM; CATIONIC PROTEIN; PHENOTYPES; GALECTIN-10; PEROXIDASE; GRANULE; LYSOPHOSPHOLIPASE; EXACERBATIONS; DEGRANULATION;

D O I：

10.2217/bmm-2018-0280

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Eosinophilic asthma is associated with more exacerbations and differential responses to treatment. The aim of this study was to assess if CLC/Gal-10 and MBP-1 are surrogate biomarkers of eosinophilic inflammation in asthma. Methods & results: Sputum induction was performed in patients with asthma and in healthy controls. Sputum analysis revealed higher (p < 0.001) levels of CLC/Gal-10 and MBP-1 in asthmatics versus healthy controls. CLC/Gal-10 levels were highly correlated (r(s) = 0.74; p < 0.001) with sputum eosinophils; MBP-1 approached significance (r = 0.44; p = 0.07). Conclusion: Increased CLC/Gal-10 andMBP-1 levels in the sputum were strongly correlated with sputum eosinophils in patients with asthma. CLC/Gal-10 and MBP-1 may be useful biomarkers for differentiation of eosinophilic airway inflammation in asthma.

引用

页码：715 / 724

页数：10

共 37 条

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