Experimental and computational determination of tRNA dynamics

被引：54
作者：
Alexander, Rebecca W. [1 ]
Eargle, John [2 ]
Luthey-Schulten, Zaida [2 ,3 ]
机构：
[1] Wake Forest Univ, Dept Chem, Winston Salem, NC 27109 USA
[2] Ctr Biophys & Computat Biol, Urbana, IL USA
[3] Univ Illinois, Dept Chem, Urbana, IL 61801 USA
来源：
FEBS LETTERS | 2010年 / 584卷 / 02期
基金：
美国国家科学基金会;
关键词：
tRNA; Flexibility; Conformational change; Induced fit; Molecular dynamics; Translation; AMINOACYL-TRANSFER-RNA; PHENYLALANINE TRANSFER-RNA; ELONGATION-FACTOR TU; SINGLE-NUCLEOTIDE RESOLUTION; HIV-1 NUCLEOCAPSID PROTEIN; UNMODIFIED TRANSFER-RNA; MOLECULAR-DYNAMICS; ESCHERICHIA-COLI; TERTIARY STRUCTURE; 70S RIBOSOME;
D O I：
10.1016/j.febslet.2009.11.061
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
As the molecular representation of the genetic code, tRNA plays a central role in the translational machinery where it interacts with several proteins and other RNAs during the course of protein synthesis. These interactions exploit the dynamic flexibility of tRNA. In this minireview, we discuss the effects of modified bases, ions, and proteins on tRNA structure and dynamics and the challenges of observing its motions over the cycle of translation. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
引用
收藏
页码：376 / 386
页数：11
相关论文
共 119 条
[1]   HIV-1 reverse transcription initiation: A potential target for novel antivirals? [J].
Abbink, Truus E. M. ;
Berkhout, Ben .
VIRUS RESEARCH, 2008, 134 (1-2) :4-18
[2]   Activation of microhelix charging by localized helix destabilization [J].
Alexander, RW ;
Nordin, BE ;
Schimmel, P .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (21) :12214-12219
[3]   Domain-domain communication in aminoacyl-tRNA synthetases [J].
Alexander, RW ;
Schimmel, P .
PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY, VOL 69, 2001, 69 :317-349
[4]   The tRNA specificity of Thermus thermophilus EF-Tu [J].
Asahara, H ;
Uhlenbeck, OC .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (06) :3499-3504
[5]  
ASZODI A, 1993, COMPUT APPL BIOSCI, V9, P523
[6]   RNA hydration: Three nanoseconds of multiple molecular dynamics simulations of the solvated tRNA(Asp) anticodon hairpin [J].
Auffinger, P ;
Westhof, E .
JOURNAL OF MOLECULAR BIOLOGY, 1997, 269 (03) :326-341
[7]   Molecular dynamics simulations of solvated yeast tRNAAsp [J].
Auffinger, P ;
Louise-May, S ;
Westhof, E .
BIOPHYSICAL JOURNAL, 1999, 76 (01) :50-64
[8]  
Auffinger P., 2005, Handbook of RNA Biochemistry, P560
[9]   SwS: a solvation web service for nucleic acids [J].
Auffinger, Pascal ;
Hashem, Yaser .
BIOINFORMATICS, 2007, 23 (08) :1035-1037
[10]   Vibrational dynamics of transfer RNAs: Comparison of the free and synthetase-bound forms [J].
Bahar, I ;
Jernigan, RL .
JOURNAL OF MOLECULAR BIOLOGY, 1998, 281 (05) :871-884
12345678910