A simple one-pot synthesis of triflyl guanidines: access to highly substituted electron-poor guanidines

被引：8
|
作者：
Thai, Karen [1 ]
Clement, Craig W. [1 ]
Gravel, Michel [1 ]
机构：
[1] Univ Saskatchewan, Dept Chem, Saskatoon, SK S7N 5C9, Canada
来源：
TETRAHEDRON LETTERS | 2009年 / 50卷 / 47期
基金：
加拿大自然科学与工程研究理事会; 加拿大创新基金会;
关键词：
Guanidines; Isothiocyanates; Trifluoromethanesulfonamide; Regioselective alkylation;
D O I：
10.1016/j.tetlet.2009.09.040
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Unsymmetrical di- and trisubstituted triflyl guanidines are accessed through a simple, one-pot protocol from the corresponding isothiocyanate and amine. Furthermore, in the presence of base, trisubstituted triflyl guanidines are alkylated to obtain tetrasubstituted triflyl guanidines in high yields and complete regioselectivity (C) 2009 Elsevier Ltd. All rights reserved
引用
收藏
页码：6540 / 6542
页数：3
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