Molecular mechanisms mediating anti-myeloma activity of proteasome inhibitor PS-341.

被引:0
|
作者
Hideshima, T [1 ]
Mitsiades, C [1 ]
Akiyama, M [1 ]
Hayashi, T [1 ]
Chauhan, D [1 ]
Richardson, PG [1 ]
Schlossman, RL [1 ]
Podar, K [1 ]
Munshi, NC [1 ]
Mitsiades, N [1 ]
Anderson, KC [1 ]
机构
[1] Dana Farber Canc Inst, Jerome Lipper Multiple Myeloma Ctr, Boston, MA 02115 USA
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
3215
引用
收藏
页码:814A / 814A
页数:1
相关论文
共 50 条
  • [41] The oral proteasome inhibitor ONX 0912 has bone anabolic effects in addition to anti-myeloma effects
    Hurchla, Michelle A.
    Hornick, Mary C.
    Li, Aixiao
    Collins, Lynne
    Kirk, Christopher J.
    Piwnica-Worms, David
    Vij, Ravi
    Tomasson, Michael H.
    Weilbaecher, Katherine N.
    CANCER RESEARCH, 2011, 71
  • [42] Proteasome inhibitor PS-341 inhibits human myeloma cell growth in vivo and prolongs survival in a murine model
    LeBlanc, R
    Catley, LP
    Hideshima, T
    Lentzsch, S
    Mitsiades, CS
    Mitsiades, N
    Neuberg, D
    Goloubeva, O
    Pien, CS
    Adams, J
    Gupta, D
    Richardson, PG
    Munshi, NC
    Anderson, KC
    CANCER RESEARCH, 2002, 62 (17) : 4996 - 5000
  • [43] Targeting mitochondria to overcome conventional and bortezomib/proteasome inhibitor PS-341 resistance in multiple myeloma (MM) cells
    Chauhan, D
    Li, GL
    Podar, K
    Hideshima, T
    Mitsiades, C
    Schlossman, R
    Munshi, N
    Richardson, P
    Cotter, FE
    Anderson, KC
    BLOOD, 2004, 104 (08) : 2458 - 2466
  • [44] A novel HSP70 inhibitor demonstrates potent anti-myeloma activity
    Bailey, Charvann K.
    Budina, Anna
    Murphy, Maureen
    Nefedova, Yulia
    CANCER RESEARCH, 2015, 75
  • [45] BAY 43-9006, a dual raf kinase/VEGF receptor inhibitor, has significant in vitro activity in myeloma and synergizes with the proteasome inhibitor PS341.
    Kumar, S
    Timm, M
    Haug, J
    Kimlinger, T
    Kline, M
    Rajkumar, SV
    Adjei, A
    CLINICAL CANCER RESEARCH, 2005, 11 (24) : 8989S - 8989S
  • [46] Glutamine-Dependence Targeting By Asparaginase Significantly Increases Anti-Myeloma Activity of Proteasome Inhibitors
    Minetto, Paola
    Soncini, Debora
    Cagnetta, Antonia
    Guolo, Fabio
    Retali, Veronica
    Rivoli, Giulia
    Bisso, Nadia
    Di Felice, Nikki
    Miglino, Maurizio
    Canepa, Letizia
    Lemoli, Roberto Massimo
    Gobbi, Marco
    Cea, Michele
    BLOOD, 2017, 130
  • [47] A Novel Bruton's Tyrosine Kinase Inhibitor CC-292 In Combination With The Proteasome Inhibitor Carfilzomib Iimpacts Multiple Myeloma Bone Microenviroment With Resultant Anti-Myeloma Activity
    Eda, Homare
    Santo, Loredana
    Cirstea, Diana D.
    Yee, Andrew J.
    Scullen, Tyler A.
    Nemani, Neeharika
    Mishima, Yuko
    Arastu-Kapur, Shirin
    Evans, Erica
    Singh, Juswinder
    Kirk, Christopher J.
    Westlin, William F.
    Raje, Noopur S.
    BLOOD, 2013, 122 (21)
  • [48] Proteasome inhibitor PS-341 and docetaxel: sequence of administration may be crucial
    Garfield, D
    LANCET ONCOLOGY, 2001, 2 (12): : 714 - 714
  • [49] Preclinical and clinical evaluation of proteasome inhibitor PS-341 for the treatment of cancer
    Adams, J
    CURRENT OPINION IN CHEMICAL BIOLOGY, 2002, 6 (04) : 493 - 500
  • [50] Investigative cardiovascular study of the proteasome inhibitor PS-341 in the mouse.
    Rottman, J
    Csizmadia, V
    Ozkaynak, E
    Kadambi, V
    Ganley, K
    Cardoza, K
    Juedes, M
    Bouchard, P
    TOXICOLOGICAL SCIENCES, 2003, 72 : 47 - 47