Synthesis of fully protected (2R,3R,4S)-4-amino-7-guanidino-2,3-dihydroxy heptanoic acid

被引：3

作者：

Yoshino, Ryo ^{[1
]}

Tokairin, Yoshinori ^{[1
]}

Konno, Hiroyuki ^{[1
]}

机构：

[1] Yamagata Univ, Grad Sch Sci & Engn, Dept Biol Engn, Yonezawa, Yamagata 9928510, Japan

来源：

TETRAHEDRON LETTERS | 2017年 / 58卷 / 16期

基金：

日本学术振兴会;

关键词：

Unusual amino acid; Callipeltins; Guanidination; Arginine derivative; SOLID-PHASE SYNTHESIS; SPONGE LATRUNCULIA SP; CALLIPELTIN-A; CYCLIC DEPSIPEPTIDES; CYCLODEPSIPEPTIDE; DERIVATIVES; AGDHE; (2R; 3R;

D O I：

10.1016/j.tetlet.2017.03.025

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(2R,3R,4S)-4-Amino-7-guanidino-2,3-dihydroxyheptanoic acid (AGDHE), a common constituent of biologically active marine peptides, callipeltin A (1) and neamphamide A, was synthesized as its orthogonally protected derivative from L-glutamic acid in 15 steps. Guanidination by the Mitsunobu condition and osmium-catalyzed dihydroxylation of the corresponding Z-olefin were employed as the key steps. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：1604 / 1606

页数：3

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