F2-Isoprostanes as Novel Biomarkers for Type 2 Diabetes: a Review

被引：55

作者：

Kaviarasan, Subramanian ^{[2
]}

Muniandy, Sekaran ^{[1
]}

Qvist, Rajes ^{[2
]}

Ismail, Ikram S. ^{[2
]}

机构：

[1] Univ Malaya, Fac Med, Dept Mol Med, Kuala Lumpur 50603, Malaysia

[2] Univ Malaya, Med Ctr, Dept Med, Kuala Lumpur 50603, Malaysia

来源：

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION | 2009年 / 45卷 / 01期

关键词：

oxidative stress; lipid peroxidation; isoprostanes; type; 2; diabetes; HUMAN ATHEROSCLEROTIC LESIONS; LIPID-PEROXIDATION; IN-VIVO; OXIDATIVE STRESS; 8-ISO-PROSTAGLANDIN F2-ALPHA; PLATELET ACTIVATION; ISOPROSTANE PATHWAY; VASCULAR-DISEASE; OXIDANT STRESS; VITAMIN-E;

D O I：

10.3164/jcbn.08-266

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Oxidative stress (OS) has been implicated as one of the major underlying mechanisms behind many acute and chronic diseases. However, the measurement of free radicals or their end products is complicated. Isoprostanes, derived from the non-enzymatic peroxidation of arachidonic acid are now considered to be reliable biomarkers of oxidant stress in the human body. Isoprostanes are involved in many of the human diseases such as type 2 diabetes. In type 2 diabetes elevated levels of F-2-Isoprostanes (F-2-IsoPs) have been observed. The measurement of bioactive F-2-IsoPs levels offers a unique noninvasive analytical tool to study the role of free radicals in physiology, oxidative stress-related diseases, and acute or chronic inflammatory conditions. Measurement of oxidative stress by various other methods lacks specificity and sensitivity. This review aims to shed light on the implemention of F-2-IsoPs measurement as a gold-standard biomarker of oxidative stress in type 2 diabetics.

引用

页码：1 / 8

页数：8

共 54 条

[1]

[Anonymous], FREE RADICALS BIOL M

[2] Cardiovascular responses to the isoprostanes iPF2α-III and iPE2-III are mediated via the thromboxane A2 receptor in vivo [J].

Audoly, LP ;

Rocca, B ;

Fabre, JE ;

Koller, BH ;

Thomas, D ;

Loeb, AL ;

Coffman, TM ;

FitzGerald, GA .

CIRCULATION, 2000, 101 (24) :2833-2840

[3] EFFECTS OF A NOVEL PROSTAGLANDIN, 8-EPI-PGF2-ALPHA, IN RABBIT LUNG INSITU [J].

BANERJEE, M ;

KANG, KH ;

MORROW, JD ;

ROBERTS, LJ ;

NEWMAN, JH .

AMERICAN JOURNAL OF PHYSIOLOGY, 1992, 263 (03) :H660-H663

[4] F2-isoprostane induced prostaglandin formation in the rabbit [J].

Basu, S .

FREE RADICAL RESEARCH, 2006, 40 (03) :273-277

[5] Carbon tetrachloride-induced lipid peroxidation: eicosanoid formation and their regulation by antioxidant nutrients [J].

Basu, S .

TOXICOLOGY, 2003, 189 (1-2) :113-127

[6] Metabolism of 8-iso-prostaglandin F2α [J].

Basu, S .

FEBS LETTERS, 1998, 428 (1-2) :32-36

[7] Radioimmunoassay of 15-keto-13,14-dihydro-prostaglandin F2α:: an index for inflammation via cyclooxygenase catalysed lipid peroxidation [J].

Basu, S .

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 1998, 58 (05) :347-352

[8] ROLE OF OXIDATIVE STRESS IN DEVELOPMENT OF COMPLICATIONS IN DIABETES [J].

BAYNES, JW .

DIABETES, 1991, 40 (04) :405-412

[9] Bronchopulmonary effects of 8-epi-PGF2α in anaesthetised guinea pigs [J].

Bernareggi, M ;

Rossoni, G ;

Berti, F .

PHARMACOLOGICAL RESEARCH, 1998, 37 (01) :75-80

[10] A QUANTITATIVE ASSESSMENT OF PLASMA HOMOCYSTEINE AS A RISK FACTOR FOR VASCULAR-DISEASE - PROBABLE BENEFITS OF INCREASING FOLIC-ACID INTAKES [J].

BOUSHEY, CJ ;

BERESFORD, SAA ;

OMENN, GS ;

MOTULSKY, AG .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1995, 274 (13) :1049-1057

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