Sirtuins-The New Important Players in Women's Gynecological Health

被引：22

作者：

Kratz, Ewa Maria ^{[1
]}

Kokot, Izabela ^{[1
]}

Dymicka-Piekarska, Violetta ^{[2
]}

Piwowar, Agnieszka ^{[3
]}

机构：

[1] Wroclaw Med Univ, Fac Pharm, Dept Lab Diagnost, Div Lab Diagnost, Borowska St 211A, PL-50556 Wroclaw, Poland

[2] Med Univ Bialystok, Dept Clin Lab Diagnost, Waszyngtona St 15A, PL-15269 Bialystok, Poland

[3] Wroclaw Med Univ, Fac Pharm, Dept Toxicol, Borowska St 211, PL-50556 Wroclaw, Poland

来源：

ANTIOXIDANTS | 2021年 / 10卷 / 01期

关键词：

sirtuins; women’ s gynecological health; markers of gynecological diseases; oxidative stress; POLYCYSTIC-OVARY-SYNDROME; OXIDATIVE STRESS; FEMALE REPRODUCTION; ESTROGEN-RECEPTOR; GENE-EXPRESSION; GRANULOSA-CELLS; CANCER-CELLS; DEVELOPMENTAL COMPETENCE; MENSTRUAL DISSEMINATION; PROGNOSTIC-SIGNIFICANCE;

D O I：

10.3390/antiox10010084

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The participation of sirtuins in the regulation of oxidative stress and inflammation lies at the basis of their possible modes of action and is related to their expression in various cell structures; their location in the mitochondria and blood plasma has been indicated as of primary importance. Despite many existing studies, research on sirtuins continues to present an opportunity to discover new functions and dependencies, especially when it comes to women's gynecological health. Sirtuins have a significant role in both the formation and the course of many gynecological diseases. Their role is particularly important and well documented in the course of the development of cancer within the female reproductive organs; however, disturbances observed in the ovary and oocyte as well as in follicular fluid are also widely investigated. Additionally, sirtuins take part in some gynecological disturbances as regulative factors in pathways associated with insulin resistance, glucose and lipids metabolism disorders. In this review, we would like to summarize the existing knowledge about sirtuins in the manner outlined above.

引用

页码：1 / 29

页数：27

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