Investigating the Role and Mechanism of Octreotide in Long Standing Diabetes-induced Cognitive Impairment in Rats

被引:0
作者
Yuan, Qi [1 ]
Feng, Jia [2 ]
机构
[1] Wuhan Univ, Publ Hlth Sect, Sci & Technol Hosp, Wuhan, Peoples R China
[2] Ninth Hosp Xian, Dept Endocrinol, 151 East Sect South Second Ring, Xian 710054, Shaanxi, Peoples R China
关键词
Oxidative stress; Diabetes; Memory; Octreotide; Neuroinflammation; Learning; SOMATOSTATIN ANALOG; IN-VIVO; INJURY;
D O I
10.5530/ijper.56.2.65
中图分类号
G40 [教育学];
学科分类号
040101 ; 120403 ;
摘要
Background: Octreotide is a somatostatin analogue and it produces beneficial effects in diabetic-neuropathy. Studies have also shown its beneficial role in Alzheimer disease. However, the role of octreotide in diabetes-induced cognitive impairment is not explored yet. Aim: The present study was designed to explore the role and mechanism of octreotide in long standing diabetes-induced cognitive impairment in an experimental model. Materials and Methods: Streptozotocin (60 mg/kg)-injected rats were kept for 10 weeks to induce the development of cognitive impairment, which was assessed using Morris Water Maze test. The learning was assessed by comparing the escape latency time (ELT) of day 1 with ELT of day 4. The memory was assessed on the 5th day by measuring the time spent in target quadrant (TSTQ). Three different doses of octreotide (10, 20 and 40 mu g/kg) were administered for the last two weeks. The levels of Nrf2, reduced glutathione, TBARS, IL-1 and TNF-alpha were measured in rat brain homogenates. Results: Treatment with octreotide for two weeks led to significant increase in day 4 ELT and day 5 TSTQ in streptozotocin-injected rats suggesting the improvement in learning and memory. Moreover, octreotide attenuated streptozotocin-induced increase in neuroinflammation and oxidative stress. It also increased the nuclear: cytoplasmic ratio of Nrf2 suggesting the effect of octreotide in increasing the levels of endogenous antioxidants. Conclusion: Octreotide has the potential to improve learning and memory in long standing diabetes-induced cognitive dysfunction and its beneficial effects may be possibly attributed to decrease in neuroinflammation and oxidative stress.
引用
收藏
页码:448 / 454
页数:7
相关论文
共 31 条
  • [1] Aqueous extract of Digitaria exilis grains ameliorate diabetes in streptozotocin-induced diabetic male Wistar rats
    Adams, Dele Moses
    Yakubu, Musa Toyin
    [J]. JOURNAL OF ETHNOPHARMACOLOGY, 2020, 249
  • [2] Somatostatin analogue, Octreotide, improves restraint stress-induced liver injury by ameliorating oxidative stress, inflammatory response, and activation of hepatic stellate cells
    Aziz, Neven Makram
    Ragy, Merhan Mamdouh
    Ahmed, Sabreen Mahmoud
    [J]. CELL STRESS & CHAPERONES, 2018, 23 (06) : 1237 - 1245
  • [3] INVIVO INHIBITORY EFFECT OF LANREOTIDE (BIM-23014), A NEW SOMATOSTATIN ANALOG, ON PROSTAGLANDIN-STIMULATED AND CHOLERA TOXIN-STIMULATED INTESTINAL FLUID IN THE RAT
    BOTELLA, A
    VABRE, F
    FIORAMONTI, J
    THOMAS, F
    BUENO, L
    [J]. PEPTIDES, 1993, 14 (02) : 297 - 301
  • [4] Morris Water Maze Test for Learning and Memory Deficits in Alzheimer's Disease Model Mice
    Bromley-Brits, Kelley
    Deng, Yu
    Song, Weihong
    [J]. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2011, (53):
  • [5] Anti-inflammatory Effect of Somatostatin Analogue Octreotide on Rheumatoid Arthritis Synoviocytes
    Casnici, Claudia
    Lattuada, Donatella
    Crotta, Katia
    Truzzi, Marcello Claudio
    Corradini, Costantino
    Ingegnoli, Francesca
    Tonna, Noemi
    Bianco, Fabio
    Marelli, Ornella
    [J]. INFLAMMATION, 2018, 41 (05) : 1648 - 1660
  • [6] The protection by Octreotide against experimental ischemic stroke: Up-regulated transcription factor Nrf2, HO-1 and down-regulated NF-κB expression
    Chen, Linyu
    Wang, Lina
    Zhang, Xiangjian
    Cui, Lili
    Xing, Yinxue
    Dong, Lipeng
    Liu, Zongjie
    Li, Yanhua
    Zhang, Xiaolin
    Wang, Chaohui
    Bai, Xue
    Zhang, Jian
    Zhang, Lan
    Zhao, Xumeng
    [J]. BRAIN RESEARCH, 2012, 1475 : 80 - 87
  • [7] Cheng Zhentian, 2019, Panminerva Med, DOI 10.23736/S0031-0808.19.03711-X
  • [8] Octreotide (somatostatin analog) treatment reduces endothelial cell dysfunction in patients with diabetes mellitus
    Clemens, A
    Klevesath, MS
    Hofmann, M
    Raulf, F
    Henkels, M
    Amiral, J
    Seibel, MJ
    Zimmermann, J
    Ziegler, R
    Wahl, P
    Nawroth, PP
    [J]. METABOLISM-CLINICAL AND EXPERIMENTAL, 1999, 48 (10): : 1236 - 1240
  • [9] Dai GF, 2018, EUR REV MED PHARMACO, V22, P6139, DOI 10.26355/eurrev_201809_15954
  • [10] Comparison of the effects of octreotide and melatonin in preventing nerve injury in rats with experimental spinal cord injury
    Erol, Fatih S.
    Kaplan, Metin
    Tiftikci, Murat
    Yakar, Huseyin
    Ozercan, Ibrahim
    Ilhan, Necip
    Topsakal, Cahide
    [J]. JOURNAL OF CLINICAL NEUROSCIENCE, 2008, 15 (07) : 784 - 790