Synthesis of 3,3-disubstituted oxindoles

被引：26
|
作者：
Liu, Kevin G. [1 ]
Robichaud, Albert J. [1 ]
机构：
[1] Wyeth Res, Chem & Screeing Sci, Princeton, NJ 08543 USA
来源：
TETRAHEDRON LETTERS | 2007年 / 48卷 / 03期
关键词：
D O I：
10.1016/j.tetlet.2006.11.041
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel and efficient two-step synthetic sequence for the preparation of 3,3-disubstituted oxindoles was developed starting from arylhydrazines and alpha-branched aldehydes via Fischer indole type synthesis followed by imine oxidation. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：461 / 463
页数：3
相关论文
共 50 条
  • [1] The synthesis of symmetrical 3,3-Disubstituted oxindoles by phosphin-ecatalyzed γ/γ-addition of oxindoles with allenoates
    Zhang, Ji-Quan
    Li, Shu-Min
    Wu, Chun-Feng
    Wang, Xing-Lan
    Wu, Ting-Ting
    Du, Yao
    Yang, Yuan-Yong
    Fan, Ling-Ling
    Dong, Yong-Xi
    Wang, Jian-Ta
    Tang, Lei
    CATALYSIS COMMUNICATIONS, 2020, 138
  • [2] Chiral Bifunctional Thiosquaramides as Organocatalysts in the Synthesis of Enantioenriched 3,3-Disubstituted Oxindoles
    Rodriguez-Ferrer, Patricia
    Naharro, Daniel
    Maestro, Alicia
    Andres, Jose M.
    Pedrosa, Rafael
    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2019, 2019 (38) : 6539 - 6549
  • [3] Modular synthesis of 3,3-disubstituted oxindoles from nitrones and acrylic acids
    Suzuki, Hirotsugu
    Sekino, Kaisei
    Kondo, Sora
    Minamikawa, Ryo
    Matsuda, Takanori
    ORGANIC & BIOMOLECULAR CHEMISTRY, 2024, 22 (31) : 6282 - 6287
  • [4] Domino Carbopalladation-Cross-Coupling for the Synthesis of 3,3-Disubstituted Oxindoles
    Seashore-Ludlow, Brinton
    Somfai, Peter
    ORGANIC LETTERS, 2012, 14 (15) : 3858 - 3861
  • [5] Catalytic asymmetric synthesis of 3,3-disubstituted oxindoles: diazooxindole joins the field
    Cao, Zhong-Yan
    Wang, Yu-Hui
    Zeng, Xing-Ping
    Zhou, Jian
    TETRAHEDRON LETTERS, 2014, 55 (16) : 2571 - 2584
  • [6] Nickel-Catalyzed Intramolecular Arylcyanation for the Synthesis of 3,3-Disubstituted Oxindoles
    Yen, Andy
    Lautens, Mark
    ORGANIC LETTERS, 2018, 20 (14) : 4323 - 4327
  • [7] Synthesis of 3,3-Disubstituted 2-Oxindoles by Deacylative Alkylation of 3-Acetyl-2-oxindoles
    Ortega-Martinez, Aitor
    Molina, Cynthia
    Moreno-Cabrerizoa, Cristina
    Sansano, Jose M.
    Najera, Carmen
    SYNTHESIS-STUTTGART, 2017, 49 (23): : 5203 - 5210
  • [8] Preparation of 3,3-disubstituted oxindoles by addition of malonates to 3-halo-3-oxindoles
    Krishnan, Shyam
    Stoltz, Brian M.
    TETRAHEDRON LETTERS, 2007, 48 (43) : 7571 - 7573
  • [9] Enantioselective synthesis of 3,3-disubstituted oxindoles through Pd-catalyzed cyanoamidation
    Yasui, Yoshimmi
    Kamisaki, Haruhi
    Takemoto, Yoshiji
    ORGANIC LETTERS, 2008, 10 (15) : 3303 - 3306
  • [10] Development of Synthetic Methodologies via Catalytic Enantioselective Synthesis of 3,3-Disubstituted Oxindoles
    Cao, Zhong-Yan
    Zhou, Feng
    Zhou, Jian
    ACCOUNTS OF CHEMICAL RESEARCH, 2018, 51 (06) : 1443 - 1454
12345