Hyperbaric oxygen therapy as an anti-infective agent

被引：57

作者：

Cimsit, Maide ^{[3
]}

Uzun, Guenalp ^{[2
]}

Yildiz, Senol ^{[1
]}

机构：

[1] Gulhane Mil Med Acad, Dept Underwater & Hyperbar Med, TR-06018 Ankara, Turkey

[2] Haydarpas Teaching Hosp, Gulhane Mil Med Acad, Dept Underwater & Hyperbar Med, TR-34668 Istanbul, Turkey

[3] Istanbul Univ, Fac Med, Dept Underwater & Hyperbar Med, Istanbul, Turkey

来源：

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY | 2009年 / 7卷 / 08期

关键词：

diabetic foot infection; gas gangrene; hyperbaric oxygenation; hypoxia; necrotizing fasciitis; osteomyelitis; FASCIITIS REDUCES MORTALITY; NECROTIZING FASCIITIS; DIABETIC FOOT; EXPERIMENTAL OSTEOMYELITIS; ESCHERICHIA-COLI; GAS-GANGRENE; PSEUDOMONAS-AERUGINOSA; STAPHYLOCOCCUS-AUREUS; INSPIRED OXYGEN; INFECTIONS;

D O I：

10.1586/ERI.09.76

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Hyperbaric oxygen therapy (HBOT) involves inhalation of 100% oxygen at supra-atmospheric ambient pressure. HBOT is used as either a primary or adjunctive treatment in the management of infections such as gas gangrene, necrotizing fasciitis, diabetic foot infections, refractory osteomyelitis, neurosurgical infections and fungal infections. HBOT acts as a bactericidal/bacteriostatic agent against anerobic bacteria by increasing the formation of free oxygen radicals. HBOT restores the bacterial-killing capacity of leukocytes in hypoxic wounds by increasing tissue oxygen tensions. In addition, HBOT acts synergistically with a number of antibiotics. This article reviews the anti-infective effects of HBOT and the use of HBOT in the treatment of certain infectious diseases.

引用

页码：1015 / 1026

页数：12

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