Microwave-assisted synthesis of benzoxazole-7-carboxylate esters using trifluoroacetic acid and acetic acid

被引：10

作者：

Huxley, Anthony ^{[1
]}

机构：

[1] GlaxoSmithKline Inc, GI Ctr Excellence Drug Discovery, Harlow CM19 5AW, Essex, England

来源：

SYNLETT | 2006年 / 16期

关键词：

benzoxazoles; heterocycles; cyclisations; acylations; microwave-assisted synthesis; trifluoroacetic acid;

D O I：

10.1055/s-2006-951489

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Existing routes to benzoxazole-7-carboxylates are low-yielding. The following letter describes a new methodology for the synthesis of benzoxazole-7-carboxylates in much improved yield using trifluoroacetic acid-acetic acid and microwave irradiation.

引用

页码：2658 / 2660

页数：3

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