Rosmarinic acid protects rats against post-stroke depression after transient focal cerebral ischemic injury through enhancing antioxidant response

被引:31
作者
Wang, Jiajia [1 ]
Wang, Shiquan [1 ]
Guo, Haiyun [1 ]
Li, Yi [1 ]
Jiang, Zhenhua [1 ]
Gu, Ting [1 ]
Su, Binxiao [1 ]
Hou, Wugang [1 ]
Zhong, Haixing [1 ]
Cheng, Dandan [1 ]
Zhang, Xijing [1 ]
Fang, Zongping [1 ]
机构
[1] Fourth Mil Med Univ, Xijing Hosp, Dept Anesthesiol, Xian 710032, Shaanxi, Peoples R China
关键词
Cerebral ischemia; Rosmarinic acid; Post-stroke depression; Middle cerebral artery occlusion; BLOOD-BRAIN-BARRIER; OXIDATIVE STRESS; IN-VITRO; STROKE; MECHANISMS; FREQUENCY; MODEL; MICE;
D O I
10.1016/j.brainres.2021.147336
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Rosmarinic acid (RA), a natural polyphenol, possesses potent antioxidant and anti-inflammatory activities. To evaluate the ability of RA to cure ischemic stroke and post-stroke depression (PSD), rats were treated with various doses of RA after cerebral ischemia. Neurological deficits and infarct volume of the brain were measured. The activities of superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH) were examined at different time points. In addition, a forced swimming test and sucrose preference test were performed to detect the antidepressive effects of RA. Our results revealed RA administration significantly alleviated neurological deficits and reduced infarct volumes. RA attenuated the decrease of SOD, CAT activities and GSH levels in the ischemic penumbra of the brain. Most importantly, RA treatment alleviated the depression behaviors. Increased expression of Nrf2 was also induced by RA, while down regulation Nrf2 by Nrf2-short-hairpin RNA sequences reversed the increasing activity of SOD and CAT induced by RA, as well as the protection against PSD. The present study indicates that RA exerts a potent neuroprotective effect against stroke and PSD, which could be a promising therapeutic intervention for stroke.
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页数:9
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共 37 条
  • [11] Frequency of depression after stroke - A systematic review of observational studies
    Hackett, ML
    Yapa, C
    Parag, V
    Anderson, CS
    [J]. STROKE, 2005, 36 (06) : 1330 - 1340
  • [12] Role of free radicals in the neurodegenerative diseases - Therapeutic implications for antioxidant treatment
    Halliwell, B
    [J]. DRUGS & AGING, 2001, 18 (09) : 685 - 716
  • [13] Antidepressant-like effects of paeoniflorin on post-stroke depression in a rat model
    Hu, Ming-zhe
    Wang, An-rong
    Zhao, Ze-yu
    Chen, Xiang-yan
    Li, Yan-bin
    Liu, Bin
    [J]. NEUROLOGICAL RESEARCH, 2019, 41 (05) : 446 - 455
  • [14] ROSMARINIC ACID PROTECTS AGAINST EXPERIMENTAL SEPSIS BY INHIBITING PROINFLAMMATORY FACTOR RELEASE AND AMELIORATING HEMODYNAMICS
    Jiang, Wang-Lin
    Chen, Xi-Guang
    Qu, Gui-Wu
    Yue, Xi-Dian
    Zhu, Hai-Bo
    Tian, Jing-Wei
    Fu, Feng-Hua
    [J]. SHOCK, 2009, 32 (06): : 608 - 613
  • [15] Rutin protects the neural damage induced by transient focal ischemia in rats
    Khan, Mohd. Moshahid
    Ahmad, Ajmal
    Ishrat, Tauheed
    Khuwaja, Gulrana
    Srivastawa, Pallavi
    Khan, M. Badruzzaman
    Raza, Syed Shadab
    Javed, Hayate
    Vaibhav, Kumar
    Khan, Andleeb
    Islam, Fakhrul
    [J]. BRAIN RESEARCH, 2009, 1292 : 123 - 135
  • [16] Inhibitory effects of rosmarinic acid on adriamycin-induced apoptosis in H9c2 cardiac muscle cells by inhibiting reactive oxygen species and the activations of c-Jun N-terminal kinase and extracellular signal-regulated kinase
    Kim, DS
    Kim, HR
    Woo, ER
    Hong, ST
    Chae, HJ
    Chae, SW
    [J]. BIOCHEMICAL PHARMACOLOGY, 2005, 70 (07) : 1066 - 1078
  • [17] Targeted delivery of rosmarinic acid across the blood-brain barrier for neuronal rescue using polyacrylamide-chitosan-poly(lactide-co-glycolide) nanoparticles with surface cross-reacting material 197 and apolipoprotein E
    Kuo, Yung-Chih
    Rajesh, Rajendiran
    [J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2017, 528 (1-2) : 228 - 241
  • [18] The Neuro-Protective Effect of the Methanolic Extract of Perilla frutescens var. japonica and Rosmarinic Acid against H2O2-Induced Oxidative Stress in C6 Glial Cells
    Lee, Ah Young
    Wu, Ting Ting
    Hwang, Bo Ra
    Lee, Jaemin
    Lee, Myoung-Hee
    Lee, Sanghyun
    Cho, Eun Ju
    [J]. BIOMOLECULES & THERAPEUTICS, 2016, 24 (03) : 338 - 345
  • [19] In vitro and in vivo antifibrotic effects of rosmarinic acid on experimental liver fibrosis
    Li, Gui-Sheng
    Jiang, Wang-Lin
    Tian, Jing-Wei
    Qu, Gui-Wu
    Zhu, Hai-Bo
    Fu, Feng-Hua
    [J]. PHYTOMEDICINE, 2010, 17 (3-4) : 282 - 288
  • [20] Pharmacokinetics, tissue distribution, metabolism, and excretion of depside salts from Salvia miltiorrhiza in rats
    Li, Xiaochuan
    Yu, Chen
    Lu, Youli
    Gu, Yunlong
    Lu, Jie
    Xu, Wei
    Xuan, Lijiang
    Wang, Yiping
    [J]. DRUG METABOLISM AND DISPOSITION, 2007, 35 (02) : 234 - 239