γδ T Cell Receptors without a Job

被引:26
作者
Kapsenberg, Martien L. [1 ]
机构
[1] Univ Amsterdam, Dept Cell Biol & Histol, Acad Med Ctr, NL-1105 AZ Amsterdam, Netherlands
关键词
IL-17;
D O I
10.1016/j.immuni.2009.08.004
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In this issue of Immunity, the studies by Sutton et al. (2009) and Martin et al. (2009) indicate that gamma delta T cells are innate cells that rapidly produce interleukin (IL)-17 in response to cytokines or pathogens without the need for T cell receptor engagement.
引用
收藏
页码:181 / 183
页数:3
相关论文
共 10 条
[1]   Cutting Edge: IL-23 Receptor GFP Reporter Mice Reveal Distinct Populations of IL-17-Producing Cells [J].
Awasthi, Amit ;
Riol-Blanco, Lorena ;
Jaeger, Anneli ;
Korn, Thomas ;
Pot, Caroline ;
Galileos, George ;
Bettelli, Estelle ;
Kuchroo, Vijay K. ;
Oukka, Mohamed .
JOURNAL OF IMMUNOLOGY, 2009, 182 (10) :5904-5908
[2]   Thymic selection determines γδ T cell effector fate:: Antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon γ [J].
Jensen, Kirk D. C. ;
Su, Xiaoqin ;
Shin, Sunny ;
Li, Luke ;
Youssef, Sawsan ;
Yarnasaki, Sho ;
Steinman, Lawrence ;
Saito, Takashi ;
Locksley, Richard M. ;
Davis, Mark M. ;
Baumgarth, Nicole ;
Chien, Yueh-Hsiu .
IMMUNITY, 2008, 29 (01) :90-100
[3]   IL-17 and Th17 Cells [J].
Korn, Thomas ;
Bettelli, Estelle ;
Oukka, Mohamed ;
Kuchroo, Vijay K. .
ANNUAL REVIEW OF IMMUNOLOGY, 2009, 27 :485-517
[4]   In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORγt+ T cells [J].
Lochner, Matthias ;
Peduto, Lucie ;
Cherrier, Marie ;
Sawa, Shinichiro ;
Langa, Francina ;
Varona, Rosa ;
Riethmacher, Dieter ;
Si-Tahar, Mustapha ;
Di Santo, James P. ;
Eberl, Gerard .
JOURNAL OF EXPERIMENTAL MEDICINE, 2008, 205 (06) :1381-1393
[5]   Interleukin-17-Producing γδ T Cells Selectively Expand in Response to Pathogen Products and Environmental Signals [J].
Martin, Bruno ;
Hirota, Keiji ;
Cua, Daniel J. ;
Stockinger, Brigitta ;
Veldhoen, Marc .
IMMUNITY, 2009, 31 (02) :321-330
[6]   A protective function for interleukin 17A in T cell-mediated intestinal inflammation [J].
O'Connor, William, Jr. ;
Kamanaka, Masahito ;
Booth, Carmen J. ;
Town, Terrence ;
Nakae, Susumu ;
Iwakura, Yoichiro ;
Kolls, Jay K. ;
Flavell, Richard A. .
NATURE IMMUNOLOGY, 2009, 10 (06) :603-U65
[7]  
OBRIEN RL, 2008, EUR J IMMUNOL, V39, P634
[8]   γδ T cell:: an important source of IL-17 [J].
Roark, Christina L. ;
Simonian, Philip L. ;
Fontenot, Andrew P. ;
Born, Willi K. ;
O'Brien, Rebecca L. .
CURRENT OPINION IN IMMUNOLOGY, 2008, 20 (03) :353-357
[9]   Identification of CD25+ γδ T Cells As Fetal Thymus-Derived Naturally Occurring IL-17 Producers [J].
Shibata, Kensuke ;
Yamada, Hisakata ;
Nakamura, Risa ;
Sun, Xun ;
Itsumi, Momoe ;
Yoshikai, Yasunobu .
JOURNAL OF IMMUNOLOGY, 2008, 181 (09) :5940-5947
[10]   Interleukin-1 and IL-23 Induce Innate IL-17 Production from γδ T Cells, Amplifying Th17 Responses and Autoimmunity [J].
Sutton, Caroline E. ;
Lalor, Stephen J. ;
Sweeney, Cheryl M. ;
Brereton, Corinna F. ;
Lavelle, Ed C. ;
Mills, Kingston H. G. .
IMMUNITY, 2009, 31 (02) :331-341