Pathogenesis of urinary tract infections. An update

被引：5

作者：

Magistro, G. ^{[1
]}

Marcon, J. ^{[1
]}

Schubert, S. ^{[2
]}

Gratzke, C. ^{[1
]}

Stief, C. G. ^{[1
]}

机构：

[1] Ludwig Maximilians Univ Munchen, Univ Munchen, Urol Klin & Poliklin, Campus Grosshadern, D-81377 Munich, Germany

[2] Ludwig Maximilians Univ Munchen, Max von Pettenkofer Inst Hyg & Med Mikrobiol, Munich, Germany

来源：

UROLOGE | 2017年 / 56卷 / 06期

关键词：

Intracellular bacterial communities; Virulence factors; Antibiotics; Urinary tract; Bacteriuria; UROPATHOGENIC ESCHERICHIA-COLI; INTRACELLULAR BACTERIAL COMMUNITIES; FIMH-ADHESIN; PERSISTENCE; INVASION; PROTECTS; PYELONEPHRITIS; SUSCEPTIBILITY; MECHANISMS; PREVENTION;

D O I：

10.1007/s00120-017-0391-7

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Urinary tract infections are among the most common bacterial infections worldwide. The management has become a public health concern of socioeconomic importance. Every second woman will experience at least one episode in her lifetime. Due to the emergence of multiresistant pathogens and the developmental void, treatment has become more challenging over the years. Deciphering the complex molecular interaction between host and pathogen is necessary to identify potent treatment targets for future approaches. The objective of this review is to present novel aspects on the pathogenesis of urinary tract infections and its relevance for clinical practice.

引用

页码：720 / 727

页数：8

共 68 条

[1] Mucosal Immunization with Iron Receptor Antigens Protects against Urinary Tract Infection [J].

Alteri, Christopher J. ;

Hagan, Erin C. ;

Sivick, Kelsey E. ;

Smith, Sara N. ;

Mobley, Harry L. T. .

PLOS PATHOGENS, 2009, 5 (09)

[2] Intracellular bacterial biofilm-like pods in urinary tract infections [J].

Anderson, GG ;

Palermo, JJ ;

Schilling, JD ;

Roth, R ;

Heuser, J ;

Hultgren, SJ .

SCIENCE, 2003, 301 (5629) :105-107

[3] Host subversion by formation of intracellular bacterial communities in the urinary tract [J].

Anderson, GG ;

Martin, SM ;

Hultgren, SJ .

MICROBES AND INFECTION, 2004, 6 (12) :1094-1101

[4] Urothelial Cultures Support Intracellular Bacterial Community Formation by Uropathogenic Escherichia coli [J].

Berry, Ruth E. ;

Klumpp, David J. ;

Schaeffer, Anthony J. .

INFECTION AND IMMUNITY, 2009, 77 (07) :2762-2772

[5] Cyclic AMP-regulated exocytosis of Escherichia coli from infected bladder epithelial cells [J].

Bishop, Brian L. ;

Duncan, Mathew J. ;

Song, Jeongmin ;

Li, Guojie ;

Zaas, David ;

Abraham, Soman N. .

NATURE MEDICINE, 2007, 13 (05) :625-630

[6] Persistence of Uropathogenic Escherichia coli in the Face of Multiple Antibiotics [J].

Blango, Matthew G. ;

Mulvey, Matthew A. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2010, 54 (05) :1855-1863

[7] Immunization with the Yersiniabactin Receptor, FyuA, Protects against Pyelonephritis in a Murine Model of Urinary Tract Infection [J].

Brumbaugh, Ariel R. ;

Smith, Sara N. ;

Mobley, Harry L. T. .

INFECTION AND IMMUNITY, 2013, 81 (09) :3309-3316

[8]

Brumbaugh AR, 2012, EXPERT REV VACCINES, V11, P663, DOI [10.1586/erv.12.36, 10.1586/ERV.12.36]

[9] Treatment and Prevention of Urinary Tract Infection with Orally Active FimH Inhibitors [J].

Cusumano, Corinne K. ;

Pinkner, Jerome S. ;

Han, Zhenfu ;

Greene, Sarah E. ;

Ford, Bradley A. ;

Crowley, Jan R. ;

Henderson, Jeffrey P. ;

Janetka, James W. ;

Hultgren, Scott J. .

SCIENCE TRANSLATIONAL MEDICINE, 2011, 3 (109)

[10]

Darouiche RO, 2011, UROLOGY, V78, P341, DOI 10.1016/j.urology.2011.03.062

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