Isotactic polyethylenimines induce formation of L-amino acids in transamination

被引：34

作者：

Bandyopadhyay, Subhajit ^{[1
]}

Zhou, Wenjun ^{[1
]}

Breslow, Ronald ^{[1
]}

机构：

[1] Columbia Univ, Dept Chem, New York, NY 10027 USA

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 06期

关键词：

D O I：

10.1021/ol0630604

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Isotactic polyethylenimines with (S)-benzyl side chains were synthesized from 4-(S)-4-benzyl-2-oxazolines. When alpha-keto acids were subjected to transamination in the presence of this polymer, and a pyridoxamine coenzyme modified with hydrophobic chains, enantioselectivity toward the natural isomer (L > D) was observed, followed by racemization of the amino acid products. However, the racemization did not occur when the coenzyme was covalently attached to the polymer.

引用

页码：1009 / 1012

页数：4

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