Highly enantiofacial protonation of prochiral lithium enolates with chiral beta-hydroxy sulfoxides

被引：37
作者：
Kosugi, H
Hoshino, K
Uda, H
机构：
[1] Inst. for Chemical Reaction Science, Tohoku University, Sendai 980-77, Katahira, Aoba-ku
来源：
TETRAHEDRON LETTERS | 1997年 / 38卷 / 39期
关键词：
D O I：
10.1016/S0040-4039(97)01618-3
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Highly enantioselective protonation of prochiral lithium enolates is disclosed. The present method employed (S,R-S)-CF3-hydroxy sulfoxide (3b) as the chiral protonating agent, and the protonation of lithium enolates of cyclohexanone derivatives with 3b proceeded with high enantioselectivities. (C) 1997 Elsevier Science Ltd.
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页码：6861 / 6864
页数：4
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