Echocardiographic Findings and NT-proBNP Level in Type-2 Diabetic Patients With and Without Ischemic Heart Disease

被引：4
|
作者：
Castano Rodriguez, Sara [1 ]
Coma-Canella, Isabel [1 ]
Lopez Salazar, Begona [2 ]
Barba Cosials, Joaquin [1 ]
机构：
[1] Univ Navarra Clin, Dept Cardiol, Avda Pio XII,36, Navarra 31008, Spain
[2] Univ Navarra, Area Ciencias Cardiovasc, Ctr Invest, Clin Aplicada CIMA, Navarra, Spain
来源：
REVISTA ESPANOLA DE CARDIOLOGIA | 2009年 / 62卷 / 10期
关键词：
Diabetic cardiomyopathy; Ischemic heart disease; Diastolic dysfunction; BNP;
D O I：
10.1016/S0300-8932(09)72388-7
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The aim of this study was to determine whether there are differences in echocardiographic findings or in the level of a biochemical marker (i.e. N-terminal probrain natriuretic peptide [NT-proBNP]) between controls and type-2 diabetic patients with or without ischemic heart disease. Echocardiography was used to assess left ventricular function and morphology. In addition, the plasma NT-proBNP concentration was measured. The prevalence of diastolic dysfunction was greater in diabetics without ischemic heart disease than in controls (88% vs. 74%, respectively; P<.001) and the NT-proBNP concentration was higher (350.6+/-197.8 vs. 281.7+/-190.4 fmol/mL; P<.001). Diabetics with ischemic heart disease had a higher NT-proBNP concentration than those without (720.4+/-278.1 vs. 350.6+/-197.8 fmol/mL, respectively; P<.001). An NT-proBNP concentration >490 fmol/mL had a sensitivity of 84% and a specificity of 75% for detecting ischemic heart disease in diabetics.
引用
收藏
页码：1184 / 1188
页数：5
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