Glucagon-Like Peptide-1-Mediated Cardioprotection Does Not Reduce Right Ventricular Stunning and Cumulative Ischemic Dysfunction After Coronary Balloon Occlusion

被引：6

作者：

Giblett, Joel P. ^{[1
,2
]}

Axell, Richard G. ^{[3
]}

White, Paul A. ^{[3
]}

Aetesam-Ur-Rahman, Muhammad ^{[1
,2
]}

Clarke, Sophie J. ^{[2
]}

Figg, Nicola ^{[2
]}

Bennett, Martin R. ^{[2
]}

West, Nick E. J. ^{[1
]}

Hoole, Stephen P. ^{[1
,2
]}

机构：

[1] Royal Papworth Hosp, Dept Intervent Cardiol, Cambridge CB23 3RE, England

[2] Univ Cambridge, Div Cardiovasc Med, Cambridge, England

[3] Cambridge Univ Hosp NHS Fdn Trust, Med Phys & Clin Engn, Cambridge, England

来源：

JACC-BASIC TO TRANSLATIONAL SCIENCE | 2019年 / 4卷 / 02期

关键词：

cardioprotection; glucagon-like peptide-1; ischemia-reperfusion injury; right ventricle; PRESSURE-VOLUME; RAT-HEART; ARTERY; GLP-1; TIME; REPERFUSION; RELAXATION; MYOCARDIUM; INFUSION; PROTECTS;

D O I：

10.1016/j.jacbts.2018.12.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Stunning and cumulative ischemic dysfunction occur in the left ventricle with coronary balloon occlusion. Glucagon-like peptide (GLP)-1 protects the left ventricle against this dysfunction. This study used a conductance catheter method to evaluate whether the right ventricle (RV) developed similar dysfunction during right coronary artery balloon occlusion and whether GLP-1 was protective. In this study, the RV underwent significant stunning and cumulative ischemic dysfunction with right coronary artery balloon occlusion. However, GLP-1 did not protect the RV against this dysfunction when infused after balloon occlusion. (C) 2019 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.

引用

页码：222 / 233

页数：12

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