Merlot grape pomace hydroalcoholic extract improves the oxidative and inflammatory states of rats with adjuvant-induced arthritis

被引：67

作者：

Goncalves, Geferson A. ^{[1
,2
]}

Soares, Andreia A. ^{[2
,3
]}

Correa, Rubia C. G. ^{[2
,3
]}

Barros, Lillian ^{[4
,5
]}

Haminiuk, Charles W. I. ^{[3
]}

Peralta, Rosane M. ^{[1
,2
]}

Ferreira, Isabel C. F. R. ^{[4
]}

Bracht, Adelar ^{[1
,2
]}

机构：

[1] State Univ Maringa UEM, Grad Program Food Sci, Maringa, Parana, Brazil

[2] State Univ Maringa UEM, Dept Biochem, Maringa, Parana, Brazil

[3] Fed Univ Technol Parana UTFPR, Grad Program Food Technol, Campus Campo Mourao, Curitiba, Parana, Brazil

[4] Polytech Inst Braganca IPB, Mt Res Ctr CIMO, ESA, Campus Santa Apolonia, Braganca, Portugal

[5] Polytech Inst Braganca, LSRE LCM, Campus Santa Apolonia 1134, P-5301857 Braganca, Portugal

来源：

JOURNAL OF FUNCTIONAL FOODS | 2017年 / 33卷

关键词：

Grape pomace; Polyphenolics; Arthritis; Oxidative stress; Protein damage; Inflammation; VITIS-VINIFERA; ANTIOXIDANT ACTIVITY; BIOACTIVE COMPOUNDS; LIVER; CAPACITY; ANTHOCYANINS; METABOLISM; PROTEIN; PROFILE; STRESS;

D O I：

10.1016/j.jff.2017.04.009

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Grape pomace is an agro-industrial residue produced worldwide. The purpose of this study was to identify and quantify the main phenolics present in an hydroalcohlic extract of a Merlot grape pomace and to investigate its effect on the oxidative and inflammatory states of adjuvant-induced arthritic rats. Daily doses of 250 mg of the extract per kg body weight were administered during 23 days. Several oxidative stress indicators in arthritic rats were maintained at their normal or closely normal levels in the plasma, liver and brain by the treatment. Additionally, the grape pomace also showed significant antiinflammatory effects. From the 25 phenolics identified in the grape pomace extract the most abundant ones were catechin and catechin derivatives, which are possibly the most important antioxidant agents. The results suggest a potential applicability of the Merlot grape pomace hydroalcoholic extract in the improvement of the oxidative and inflammatory states in arthritic patients. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：408 / 418

页数：11

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