FUNCTIONAL ASSESSMENT AFTER SCIATIC NERVE INJURY IN A RAT MODEL

被引：78

作者：

Dinh, Paul ^{[1
]}

Hazel, Antony ^{[1
]}

Palispis, Winnie ^{[1
]}

Suryadevara, Sourabh ^{[1
]}

Gupta, Ranjan ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Orthopaed Surg, Irvine, CA 92697 USA

来源：

MICROSURGERY | 2009年 / 29卷 / 08期

关键词：

MACROPHAGE RECRUITMENT; SCHWANN-CELLS; TIBIAL NERVE; COMPRESSION; RECOVERY; REPAIR; DEMYELINATION; REGENERATION; SECONDARY; PATTERN;

D O I：

10.1002/micr.20685

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

The aim of this study is to evaluate the effectiveness of Sciatic Function Index (SFI) and Basso, Beattie, and Bresnahan (BBB) Locomotor Rating in assessing peripheral nerve injuries. SFI is a standard method for evaluating crush and transected peripheral nerve injuries, likewise BBB for spinal cord injury. Models of chronic nerve compression (CNC) crush, and transection injury were created on Sprague-Dawley rats and functional outcomes were measured using BBB and SFI at 1-week interval for 6 weeks. All injury models showed high correlation between SFI and BBB scores. With crush injury, the SFI showed near complete recovery while BBB showed residual deficits 6 weeks after injury. Both the BBB and SFI were unable to detect motor deficits in 6-week CNC animals. The BBB score should be considered as an adjunct in evaluating peripheral nerve recovery and may be more sensitive in detecting residual deficits than SFI after crush-type injuries. (C)2009 Wiley-Liss, Inc. Microsurgery 29:644-649, 2009.

引用

页码：644 / 649

页数：6

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