Control in the N-linked glycoprotein biosynthesis pathway

被引：15
作者：
Butters, TD [1 ]
机构：
[1] Univ Oxford, Glycobiol Inst, Oxford OX1 3QU, England
来源：
CHEMISTRY & BIOLOGY | 2002年 / 9卷 / 12期
关键词：
D O I：
10.1016/S1074-5521(02)00290-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Winked glycosylation is vital for the development and maintenance of eukaryotic cells. The individual steps of this complex process are slowly being elucidated. In this issue, the Imperiali group further dissects the mechanics of oligosaccharyl transferase using substrate analogs.
引用
收藏
页码：1266 / 1268
页数：3
相关论文
共 12 条
[1]   Targeting glycosylation as a therapeutic approach [J].
Dwek, RA ;
Butters, TD ;
Platt, FM ;
Zitzmann, N .
NATURE REVIEWS DRUG DISCOVERY, 2002, 1 (01) :65-75
[2]   ER quality control: towards an understanding at the molecular level [J].
Ellgaard, L ;
Helenius, A .
CURRENT OPINION IN CELL BIOLOGY, 2001, 13 (04) :431-437
[3]   MICE LACKING N-ACETYLGLUCOSAMINYLTRANSFERASE-I ACTIVITY DIE AT MIDGESTATION, REVEALING AN ESSENTIAL ROLE FOR COMPLEX OR HYBRID N-LINKED CARBOHYDRATES [J].
IOFFE, E ;
STANLEY, P .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (02) :728-732
[4]   GLYCOPROTEIN-SYNTHESIS AND EMBRYONIC-DEVELOPMENT [J].
LENNARZ, WJ .
CRC CRITICAL REVIEWS IN BIOCHEMISTRY, 1983, 14 (04) :257-272
[5]  
Marek KW, 1999, GLYCOBIOLOGY, V9, P1263
[6]   COMPLEX ASPARAGINE-LINKED OLIGOSACCHARIDES ARE REQUIRED FOR MORPHOGENIC EVENTS DURING POSTIMPLANTATION DEVELOPMENT [J].
METZLER, M ;
GERTZ, A ;
SARKAR, M ;
SCHACHTER, H ;
SCHRADER, JW ;
MARTH, JD .
EMBO JOURNAL, 1994, 13 (09) :2056-2065
[7]   Different conformations of nascent polypeptides during translocation across the ER membrane [J].
Mingarro I. ;
Nilsson I.M. ;
Whitley P. ;
von Heijne G. .
BMC Cell Biology, 1 (1)
[8]   Oligosaccharide transport: pumping waste from the ER into lysosomes [J].
Moore, SEH .
TRENDS IN CELL BIOLOGY, 1999, 9 (11) :441-446
[9]   Neoglycopeptides as inhibitors of oligosaccharyl transferase: Insight into negotiating product inhibition [J].
Peluso, S ;
Ufret, MD ;
O'Reilly, MK ;
Imperiali, B .
CHEMISTRY & BIOLOGY, 2002, 9 (12) :1323-1328
[10]   The solution NMR structure of glucosylated N-glycans involved in the early stages of glycoprotein biosynthesis and folding [J].
Petrescu, AJ ;
Butters, TD ;
Reinkensmeier, G ;
Petrescu, S ;
Platt, FM ;
Dwek, RA ;
Wormald, MR .
EMBO JOURNAL, 1997, 16 (14) :4302-4310
12