Anti-atherogenic properties of Deglet Noor Date seeds (Phoenix dactylifera) Methanol extract on Diet-Induced Hypercholesterolemic Rats.

被引：6

作者：

Saryono, S. ^{[1
]}

Eliyan, J. ^{[1
]}

Herdiati, D. ^{[1
]}

Khikmatullah, A. A. ^{[1
]}

Silvana, C. P. ^{[1
]}

Aadi, H. P. ^{[1
]}

机构：

[1] Univ Jenderal Soedirman, Fac Hlth Sci, Sch Nursing, Purwokerto, Indonesia

来源：

MATERIAL CHEMISTRY DEVELOPMENT FOR FUTURE MEDICINE, INDUSTRY, ENVIRONMENTAL AND BIOMATERIAL APPLICATION | 2017年 / 172卷

关键词：

PARAOXONASE; PLASMA; FAT;

D O I：

10.1088/1757-899X/172/1/012046

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

This is the first study to investigate the completely anti-atherogenic effect of Deglet Noor Date seeds methanol extract administration on diet-induced hypercholesterolemic rats. About 24 male Wistar rats were divided into 6 groups. The normal control (NC) group, Hypercholesterolemic Control (HC) group was given high cholesterol diet, and Simvastatin Control (SC) group was given 0.18 mg/200g simvastatin after high cholesterol diet induction. The treatment groups of T0.25, T0.5 and T1 were given supplementation of 0.25, 0.5 and 1 g/kg of dates seed extract after high cholesterol diet induction, respectively for 21 days. Blood was collected from orbitals plexus vein for plasma lipid profile analysis. The levels of Total Cholesterol (TC), Low-Density Lipoprotein (LDL) and Atherogenic Index (AI) values were significantly decreased (p<0.05) on diet-induced hypercholesterolemic rats after supplemented with date seeds extract (T0.25, T0.5 and T1) but not in Triglycerides (TG). Along with that, High Density Lipoprotein (HDL) level was significantly increased (p<0.05). However, the T1 group was the best anti-atherogenic activity in compared to other groups. Results showed that plasma lipid profile was significant to get better after supplemented with date seeds extract.

引用

页数：5

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