Assembly of indole-2-carboxylic acid esters through a ligand-free copper-catalysed cascade process

被引：67

作者：

Cai, Qian ^{[1
]}

Li, Zhengqiu ^{[2
]}

Wei, Jiajia ^{[1
]}

Ha, Chengyong ^{[2
]}

Pei, Duanqing ^{[1
]}

Ding, Ke ^{[1
]}

机构：

[1] Chinese Acad Sci, Guangzhou Inst Biomed, Inst Biol Chem, Key Lab Regenerat Biol, Guangzhou 510663, Guangdong, Peoples R China

[2] Chinese Acad Sci, Guangzhou Inst Chem, Key Lab Cellulose & Lignocellulos Chem, Guangzhou 510663, Guangdong, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2009年 / 48期

关键词：

NONREARRANGED MONOTERPENOID UNIT; SIMPLE INDOLE ALKALOIDS; CYTOSOLIC PHOSPHOLIPASE A(2); N-ARYLATION; NITROGEN-HETEROCYCLES; BIOLOGICAL EVALUATION; EFFICIENT SYNTHESIS; COUPLING REACTIONS; CYCLIZATION; INHIBITORS;

D O I：

10.1039/b918345k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A straightforward synthesis of indole-2-carboxylic esters was developed through a ligand-free copper-catalysed condensation/coupling/deformylation cascade process from 2-halo aryl aldehydes or ketones with ethyl isocyanoacetate. The reactions proceeded well for most of the 2-iodo-, bromo-, and chlorosubtrates under room temperature or mild conditions.

引用

页码：7581 / 7583

页数：3

共 35 条

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Koenig, Stefan G.
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TETRAHEDRON LETTERS, 2010, 51 (50) : 6549 - 6551
[2] Ligand-Free Copper-Catalyzed One-Pot Synthesis of Indole-2-carboxylic Esters
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[3] DIVERGENT SYNTHESIS OF INDOLE-2-CARBOXYLIC ACID DERIVATIVES VIA LIGAND-FREE COPPER-CATALYZED ULLMANN COUPLING REACTION
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[4] Synthesis of indole-2-carboxylic acid esters
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[8] Copper-catalysed N-arylation of pyrrole with aryl iodides under ligand-free conditions
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[9] Self-assembly of indole-2-carboxylic acid at graphite and gold surfaces
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[10] Microwave-Assisted Synthesis of Indole-2-Carboxylic Acid Esters in Ionic Liquid
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