Automated stroke volume and pulse pressure variations predict fluid responsiveness in mechanically ventilated patients with obstructive jaundice

Background and objectives: Stroke volume variation (SVV) and the pulse pressure variation (PPV) have been found to be effective in prediction fluid responsiveness especially in high risk operations. The objective of this study is to validate the ability of SVV obtained by FloTrac/Vigileo system and PPV obtained by IntelliVue MP System to predict fluid responsiveness in patients with obstructive jaundice during mechanical ventilation. Methods: Twenty-five patients with obstructive jaundice (mean serum total bilirubin 175.0 +/- 120.8 mu mol/L), who accepted volume expansion and were hemodynamically stable after induction of anesthesia, were included in the study. SVV and PPV were recorded simultaneously before and after an intravascular volume expansion. Patients with a stroke volume index (SVI) increase of more than 10% after volume expansion were considered as responders. Results: The agreement (mean bias +/- SD) between SVV and PPV was -0.2% +/- 1.56%. Before volume expansion, SVV and PPV were significantly higher in responders compared to non-responders (P< 0.001, P< 0.001). Significant correlation was observed between the baseline value of SVV and PPV and the percent change in SVI after fluid expansion (r=0.654, P< 0.001; r= 0.592, P= 0.002). Area under the receiver operating characteristic curves of SVV (0.955) and PPV (0.875) were comparable (P= 0.09). The optimal threshold values in predicting fluid responsiveness were 10% for SVV and 8% for PPV. Conclusion: In conclusion, SVV obtained by FloTrac/Vigileo system and PPV obtained by IntelliVue MP System was able to predict fluid responsiveness in patients with obstructive jaundice.