Azadirachta indica A. Juss. In Vivo Toxicity-An Updated Review

被引：31

作者：

Braga, Teresa M. ^{[1
]}

Rocha, Lidia ^{[1
]}

Chung, Tsz Yan ^{[1
]}

Oliveira, Rita F. ^{[1
]}

Pinho, Claudia ^{[1
]}

Oliveira, Ana I. ^{[1
]}

Morgado, Joaquim ^{[2
,3
]}

Cruz, Agostinho ^{[1
]}

机构：

[1] Inst Politecn Porto, Escola Super Saude, Ctr Invest Saude & Ambiente, P-4200072 Porto, Portugal

[2] Bio4Life4You, P-4460170 Porto, Portugal

[3] WHO, Mumbai 400101, Maharashtra, India

来源：

MOLECULES | 2021年 / 26卷 / 02期

关键词：

toxicity; in vivo; Azadirachta; indica; DAPHNIA-MAGNA; POSTNATAL-DEVELOPMENT; PANCREATIC-CANCER; DANIO-RERIO; NEEM TREE; EXTRACT; RATS; APOPTOSIS; LEAVES; NIMBOLIDE;

D O I：

10.3390/molecules26020252

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Neem tree, Azadirachta indica A. Juss., is known for its large spectrum of compounds with biological and pharmacological interest. These include, among others, activities that are anticancer, antibacterial, antiviral, and anti-inflammatory. Some neem compounds are also used as insecticides, herbicides, and/or antifeedants. The safety of these compounds is not always taken into consideration and few in vivo toxicity studies have been performed. The current study is a literature review of the latest in vivo toxicity of A. indica. It is divided in two major sections-aquatic animals toxicity and mammalian toxicity-each related to neem's application as a pesticide or a potential new therapeutic drug, respectively.

引用

页数：21

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