HTLV-I/HTLV-II coinfection in an AIDS patient from Sao Paulo, Brazil

被引:7
作者
Caterino-De-Araujo, A
Favero, A
De los Santos-Fortuna, E
Suleiman, J
Checo-Bianchi, L
Calabrò, ML
机构
[1] Univ Padua, Oncol Sect, Dept Oncol & Surg Sci, I-35128 Padua, Italy
[2] Adolfo Lutz Inst, Sao Paulo, Brazil
[3] IIER, Sao Paulo, Brazil
关键词
D O I
10.1089/088922200308710
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
A serological survey for HTLV infection identified an AIDS patient with HTLV-I/HTLV-II dual seroreactivity, Two further sequential blood samples were collected (samples A and B) for PCR, restriction fragment length polymorphism (RFLP), and sequence analyses of HTLV-I and HTLV-II strains. PCR analyses confirmed dual infection in both samples. Restriction digests of the env region amplified from sample A showed the presence of an HTLV-IIa subtype; the HTLV-II provirus was found to be defective in the pol and env regions In the second sample from this patient. RFLP analysis of the HTLV-II LTR region of both samples confirmed this finding and identified an a5/bzl restriction type. Nucleotide sequence analyses revealed full homology in the HTLV-I env and LTR regions and in the HTLV-II LTR region between the two samples. These findings document the first case of an HTLV-I/HTLV-II coinfection that was fully confirmed and characterized by means of molecular analyses.
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收藏
页码:715 / 719
页数:5
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