EFSA's OpenFoodTox: An open source toxicological database on chemicals in food and feed and its future developments

被引：38

作者：

Dorne, J. L. C. M. ^{[1
]}

Richardson, J. ^{[1
]}

Livaniou, A. ^{[1
]}

Carnesecchi, E. ^{[2
,4
,10
]}

Ceriani, L. ^{[5
]}

Baldin, R. ^{[5
]}

Kovarich, S. ^{[5
]}

Pavan, M. ^{[5
]}

Saouter, E. ^{[6
,11
]}

Biganzoli, F. ^{[6
]}

Pasinato, L. ^{[1
]}

Jeddi, M. Zare ^{[1
,2
]}

Robinson, T. P. ^{[1
]}

Kass, G. E. N. ^{[1
]}

Liem, A. K. D. ^{[1
]}

Toropov, A. A. ^{[3
]}

Toropova, A. P. ^{[3
]}

Yang, C. ^{[7
]}

Tarkhov, A. ^{[7
]}

Georgiadis, N. ^{[8
]}

Di Nicola, M. R. ^{[9
]}

Mostrag, A. ^{[7
]}

Verhagen, H. ^{[1
]}

Roncaglioni, A. ^{[2
]}

Benfenati, E. ^{[2
]}

Bassan, A. ^{[3
,12
]}

机构：

[1] European Food Safety Author, Via Carlo Magno 1A, I-43126 Parma, Italy

[2] Ist Ric Farmacol Mario Negri, Via La Masa 19, I-20156 Milan, Italy

[3] Univ Utrecht, Inst Risk Assessment Sci IRAS, POB 80177, NL-3508 TD Utrecht, Netherlands

[4] S Soluz Informat, Via Ferrari 14, I-36100 Vicenza, Italy

[5] European Commiss, Joint Res Ctr JRC, Ispra, Italy

[6] MN AM, D-90411 Nurnberg, Germany

[7] European Chem Agcy, Helsinki, Finland

[8] Via Bobbio, I-20144 Milan, Italy

[9] Univ Ulster, Coleraine, Londonderry, North Ireland

[10] EHS, Environm Directorate, Org Econ Cooperat & Dev OECD, 2 Rue Andre Pascal, F-75775 Paris 16, France

[11] World Business Council Sustainable Dev, Geneva, Switzerland

[12] Innovatune Srl, Via Zanon 130, Padua, Italy

来源：

ENVIRONMENT INTERNATIONAL | 2021年 / 146卷

关键词：

OpenFoodTox; Hazard assessment; Toxicology; Ecotoxicology; Risk assessment; In silico models;

D O I：

10.1016/j.envint.2020.106293

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Since its creation in 2002, the European Food Safety Authority (EFSA) has produced risk assessments for over 5000 substances in >2000 Scientific Opinions, Statements and Conclusions through the work of its Scientific Panels, Units and Scientific Committee. OpenFoodTox is an open source toxicological database, available both for download and data visualisation which provides data for all substances evaluated by EFSA including substance characterisation, links to EFSA's outputs, applicable legislations regulations, and a summary of hazard identification and hazard characterisation data for human health, animal health and ecological assessments. The database has been structured using OECD harmonised templates for reporting chemical test summaries (OHTs) to facilitate data sharing with stakeholders with an interest in chemical risk assessment, such as sister agencies, international scientific advisory bodies, and others. This manuscript provides a description of OpenFoodTox including data model, content and tools to download and search the database. Examples of applications of OpenFoodTox in chemical risk assessment are discussed including new quantitative structure-activity relationship (QSAR) models, integration into tools (OECD QSAR Toolbox and AMBIT-2.0), assessment of environmental footprints and testing of threshold of toxicological concern (TTC) values for food related compounds. Finally, future developments for OpenFoodTox 2.0 include the integration of new properties, such as physico-chemical properties, exposure data, toxicokinetic information; and the future integration within in silico modelling platforms such as QSAR models and physiologically-based kinetic models. Such structured in vivo, in vitro and in silico hazard data provide different lines of evidence which can be assembled, weighed and integrated using harmonised Weight of Evidence approaches to support the use of New Approach Methodologies (NAMs) in chemical risk assessment and the reduction of animal testing.

引用

页数：13

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