Microcirculation and cardiodynamics in IHD patients with low left ventricular ejection fraction and their response to carvedilol

Aim. Assessment of microcirculation in IHD patients at preclinical stage or in those with initial symptoms of cardiac failure, clarification of relationship between parameters of microcirculation and cardiodynamics. Material and methods. A blind cross-over trial was made to compare skin microcirculation and cardiodynamic parameters in response to a short carvedilol course and beta-blocker anaprilin in 40 patients. with ischemic heart disease with angina of effort (NYHA class I-IV, ejection fraction under 45%). Results. IHD with initial symptoms of cardiac failure had a congestion-spastic type of microcirculation defect. Microcirculatory picture and cardiodynamics were related. Conclusion. Compared to anaprilin therapy, treatment with carvedilol enhanced capillary blood flow and improved cardiodynamics.